ArticleNature communications2023
Functional alterations of the prefrontal circuit underlying cognitive aging in mice.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
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- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- Photosensitivity of an aging brain.bioRxiv : the preprint server for biology · 2025Article
- Profiling mouse behavior with computational tools to assess age-dependent differences in associative learning.Cell reports methods · 2025Article
- Paying attention to proprioception: age affects ankle proprioception and the attentional demand of proprioceptive processing in sedentary adults.GeroScience · 2025Article
- Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances.Signal transduction and targeted therapy · 2025Review
- Aging disrupts the link between network centrality and functional properties of prefrontal neurons during memory-guided behavior.Communications biology · 2025Article
- Cortical VIP neurons as a critical node for dopamine actions.Science advances · 2025Article
- Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice.Frontiers in aging neuroscience · 2025Article
- Peripheral CD4Immunity & ageing : I & A · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Age-related changes of dopamine D1 and D2 receptors expression in parvalbumin-positive cells of the orbitofrontal and prelimbic cortices of mice.Frontiers in neuroscience · 2024Article
- Changes in brain structure and function during early aging in patients with chronic low back pain.Frontiers in aging neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Executive function is susceptible to aging. How aging impacts the circuit-level computations underlying executive function remains unclear. Using calcium imaging and optogenetic manipulation during memory-guided behavior, we show that working-memory coding and the relevant recurrent connectivity in the mouse medial prefrontal cortex (mPFC) are altered as early as middle age. Population activity in the young adult mPFC exhibits dissociable yet overlapping patterns between tactile and auditory modalities, enabling crossmodal memory coding concurrent with modality-dependent coding. In middle age, however, crossmodal coding remarkably diminishes while modality-dependent coding persists, and both types of coding decay in advanced age. Resting-state functional connectivity, especially among memory-coding neurons, decreases already in middle age, suggesting deteriorated recurrent circuits for memory maintenance. Optogenetic inactivation reveals that the middle-aged mPFC exhibits heightened vulnerability to perturbations. These findings elucidate functional alterations of the prefrontal circuit that unfold in middle age and deteriorate further as a hallmark of cognitive aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.