Evidence map›Paper›PMID 37944754›Full record

ArticleMucosal immunology2024

Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation.

Colm B Collins, Tom T Nguyen, Robert S Leddy, Kibrom M Alula, Alyson R Yeckes, Derek Strassheim, Carol M Aherne, Marisa E Luck, Vijaya Karoor, Paul Jedlicka and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Caffeine-mediated CD39Frontiers in immunology · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Colm B CollinsMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Tom T NguyenMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Robert S LeddyConway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Kibrom M AlulaMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Alyson R YeckesMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Derek StrassheimMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Carol M AherneMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Marisa E LuckMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Vijaya KaroorDepartment of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Paul JedlickaDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Anson PierceTakeda Pharmaceuticals, Cambridge, MA, USA.
Edwin F de ZoetenMucosal Inflammation Program University of Colorado, Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: edwin.dezoeten@childrenscolorado.org.
University of Colorado Anschutz Medical Campus · USUniversity College Dublin · IETakeda (United States) · US

Funding

microRNA-dependent regulation of intestinal T-cells²R01DK111856 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DE ZOETEN, EDWIN FULCO · 2018 to 2022
$1.7M
Selective MicoRNA modification to enhance regulatory T cell function in IBDK01DK099403 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI COLLINS, COLM · 2013 to 2017
$678k
NIDDK NIH HHS K01 DK099403NIDDK NIH HHS R01 DK111856
6 · The paper itself

Abstract

The heat shock response is a critical component of the inflammatory cascade that prevents misfolding of new proteins and regulates immune responses. Activation of clusters of differentiation (CD)4

Indexed as

InflammationT-Lymphocytes, RegulatoryAnimalsForkhead Transcription FactorsHeat-Shock ResponseHeat Shock Transcription FactorsMiceMice, KnockoutMice, TransgenicForkhead Transcription FactorsHeat Shock Transcription FactorsHsf1 protein, mouse

Identifiers

PMID37944754
PMCPMC10953693
OpenAlexW4388450798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.