Evidence map›Paper›PMID 37944675›Full record

ArticleMicrobial pathogenesis2023

A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen.

Esteban Chaves-Olarte, Jazmín Meza-Torres, Fabiola Herrera-Rodríguez, Esteban Lizano-González, Marcela Suárez-Esquivel, Kate S Baker, Olga Rivas-Solano, Nazareth Ruiz-Villalobos, Fabián Villalta-Romero, Hai-Ping Cheng and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Microbial pathogenesis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Esteban Chaves-OlarteCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Jazmín Meza-TorresCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
Fabiola Herrera-RodríguezPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Esteban Lizano-GonzálezCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Marcela Suárez-EsquivelPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Kate S BakerParasites and Microbes from Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
Olga Rivas-SolanoCentro de Investigación en Biotecnología, Escuela de Biología, Instituto Tecnológico de Costa Rica, Cartago, Costa Rica.
Nazareth Ruiz-VillalobosPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Fabián Villalta-RomeroCentro de Investigación en Biotecnología, Escuela de Biología, Instituto Tecnológico de Costa Rica, Cartago, Costa Rica.
Hai-Ping ChengBiological Sciences Department, Lehman College, The City University of New York, New York, USA.
Graham C WalkerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Axel CloeckaertINRAE, Université de Tours, UMR, ISP, Nouzilly, France.
Nicholas R ThomsonParasites and Microbes from Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
Teresa FrisanDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Edgardo MorenoPrograma de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Caterina Guzmán-VerriCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica. Electronic address: catguz@una.cr.
Universidad Nacional · CRInstituto Tecnológico de Costa Rica · CRWellcome Sanger Institute · GBKarolinska Institutet · SELehman College · USMassachusetts Institute of Technology · USUniversidad de Costa Rica · CRUniversité de Tours · FR

Funding

MOLEULAR GENETICS OF RHIZOBIUM PLASMIDSR01GM031030 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WALKER, GRAHAM C · 1985 to 2020
$8.6M
NIGMS NIH HHS R01 GM031030
6 · The paper itself

Abstract

Alphaproteobacteria include organisms living in close association with plants or animals. This interaction relies partly on orthologous two-component regulatory systems (TCS), with sensor and regulator proteins modulating the expression of conserved genes related to symbiosis/virulence. We assessed the ability of the exoS

Indexed as

Brucella abortusGenes, BacterialAnimalsBacterial ProteinsGene Expression Regulation, BacterialHistidine KinaseHumansMammalsMiceVirulenceBacterial ProteinsHistidine Kinase

Identifiers

PMID37944675
PMCPMC10740080
OpenAlexW4388493984

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.