ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2023
Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 13 citations in OpenAlex.
- In-utero exposure to chikungunya and child morbimortality: a population-based study using linked routine data.Nature communications · 2026Article
- Comparative analysis of placental transmission mechanisms for Dengue and Zika viruses: outcomes and future directions.Frontiers in immunology · 2026Review
- Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior.PLoS pathogens · 2026Article
- Preexisting yellow fever virus and West Nile virus immunity and pregnancy outcomes in a Nigerian cohort with endemic orthoflavivirus exposure.Emerging microbes & infections · 2025Article
- Seropositivity to Dengue, Zika, Yellow Fever, and West Nile Viruses in Senegal, West Africa.Journal of medical virology · 2025Article
- Exposure to Dengue Virus During Pregnancy: Incidence and Impact on Maternal and Child Outcomes.The American journal of tropical medicine and hygiene · 2025Article
- Zika virus infections and associated risk factors among pregnant women in Gombe, Nigeria.Virologica Sinica · 2025Article
- Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024Article
- Assessment of knowledge and practices towards the diagnosis of arboviral infections amongst healthcare workers in Lagos State and the Federal Capital Territory: a cross-sectional study.The Pan African medical journal · 2024Article
- Addressing the Dengue fever challenges in Nigeria: A narrative review and recommendations for control.Le infezioni in medicina · 2024Review
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15 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe adverse impact of Zika (ZIKV), dengue (DENV), and chikungunya (CHIKV) virus infection in pregnancy has been recognized in Latin America and Asia but is not well studied in Africa. Although originally discovered in sub-Saharan Africa the non-specific clinical presentation of arbovirus infection may have hampered our detection of adverse clinical outcomes and outbreak.
objectiveThis prospective study of arbovirus infection in pregnant women in north-central Nigeria sought to characterize the prevalence of acute arbovirus infection and determine the impact on pregnancy and infant outcomes.
methodsIn Nigeria, we screened 1006 pregnant women for ZIKV, DENV and CHIKV IgM/IgG by rapid test (2019-2022). Women with acute infection were recruited for prospective study and infants were examined for any abnormalities from delivery through six months. A subset of rapid test-reactive samples were confirmed using virus-specific ELISAs and neutralization assays.
resultsThe prevalence of acute infection (IgM+) was 3.8 %, 9.9 % and 11.8 % for ZIKV, DENV and CHIKV, respectively; co-infections represented 24.5 % of all infections. The prevalence in asymptomatic women was twice the level of symptomatic infection. We found a significant association between acute maternal ZIKV/DENV/CHIKV infection and any gross abnormal birth outcome (p = 0.014).
conclusionsOver three rainy seasons, regular acute infection with ZIKV, DENV, and CHIKV was observed with significantly higher rates in pregnant women without symptoms. The potential association arbovirus infection with abnormal birth outcome warrants further prospective study to ascertain the clinical significance of these endemic arboviruses in Africa.
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