Evidence map›Paper›PMID 37944209›Full record

ArticlePsychoneuroendocrinology2024

Relationship between COVID-related stressors and internalizing symptoms: Gendered neuroendocrine risk profiles.

Jose M Guzman, Montana H Boone, Gabriela L Suarez, Colter Mitchell, Christopher S Monk, Luke W Hyde, Nestor L Lopez-Duran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Jose M GuzmanDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Montana H BooneDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Gabriela L SuarezDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Colter MitchellSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Christopher S MonkDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Luke W HydeDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Nestor L Lopez-DuranDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA. Electronic address: nestorl@umich.edu.
University of Michigan · US

Funding

COVID-19 supplement to a computational examination of threat and reward constructs in a predominantly low-income, longitudinal sample at increased risk for internalizing disordersR01MH121079 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYDE, LUKE WILLIAMSON, MITCHELL, COLTER M.S. · 2019 to 2024
$7.2M
Effects of poverty on affective development: A multi-level, longitudinal studyR01MH103761 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MONK, CHRISTOPHER STEPHEN · 2014 to 2018
$3.3M
The longitudinal impact of the COVID-19 pandemic and related multi-level mitigation and contextual factors on health and socioeconomic outcomes of individuals and families from a vulnerable populationU01HD110063 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLTER M.S. MITCHELL, Helen Carmon Spink Meier · 2022 to 2026
$3.0M
NICHD NIH HHS U01 HD110063NIMH NIH HHS R01 MH103761NIMH NIH HHS R01 MH121079
6 · The paper itself

Abstract

The COVID-19 pandemic generated significant life stress and increases in internalizing disorders. Moreover, COVID-related stressors disproportionately impacted women, consistent with outcomes showing a gender gap in stress-related disorders. Gender-related stress vulnerability emerges in adolescence alongside gender-specific changes in neuroendocrine signaling. Most research on the neuroendocrinology of stress-related disorders has focused on differences in the hypothalamic-pituitary-adrenal (HPA) axis effector hormone cortisol. More recent studies, however, emphasize dehydroepiandrosterone (DHEA), a neuroprotective and neuroactive hormone released concurrently with cortisol that balances its biobehavioral actions during stress. Notably, women show lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while those associations are opposite in men. Thus, gender-specific factors perhaps result in a neuroendocrine profile that places women at greater risk for stress-related disorders. The current study prospectively examined socially evaluated cold-pressor task (SECPT) induced neuroendocrine responses at age 15 and internalizing symptoms during the COVID-19 pandemic at age 21 in a cohort of 175 primarily Black low-socioeconomic status participants, while controlling for internalizing symptoms at age 15. The association between COVID-related stress and internalizing symptoms was not stronger in women. Lower DHEA-cortisol ratios were associated with a weaker relationship between COVID-related stress and internalizing symptoms in women, while higher ratios were associated with a weaker relationship in men. These findings suggest gender differences in the relationship between DHEA and cortisol and internalizing outcomes during a stressful period, and support differential neuroendocrine protective and risk pathways for young men and women.

Indexed as

COVID-19HydrocortisoneAdolescentAdultDehydroepiandrosteroneFemaleHumansHypothalamo-Hypophyseal SystemMalePandemicsPituitary-Adrenal SystemPsychophysiologic DisordersSalivaStress, PsychologicalYoung AdultDehydroepiandrosteroneHydrocortisoneCOVID-19 pandemicGender differencesHPA axisInternalizing symptomsStress

Identifiers

PMID37944209
PMCPMC11214276
OpenAlexW4388297066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.