Evidence map›Paper›PMID 37944133›Full record

SynthesisEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Durability of pulmonary vein isolation for atrial fibrillation: a meta-analysis and systematic review.

Teodor Serban, Diego Mannhart, Qurrat-Ul-Ain Abid, Andres Höchli, Sorin Lazar, Philipp Krisai, Arianna Sofia Bettelini, Sven Knecht, Michael Kühne, Christian Sticherling and 2 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pulsed field ablation for the interventional treatment of atrial fibrillation: a scientific statement of the European Heart Rhythm Association of the European Society of Cardiology, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Guideline
  2. Pooled it
  3. First-in-human clinical series of a novel conformable large-lattice pulsed field ablation catheter for pulmonary vein isolation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Trial
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  6. Compliance to direct oral anticoagulation therapy and clinical outcomes after catheter ablation for atrial fibrillation: a nationwide cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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  19. Pulmonary vein reconnection rates after pulse field ablation: time for a reality check?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  20. Left atrial intramyocardial fat at pulmonary vein reconnection sites during atrial fibrillation redo ablation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Teodor SerbanDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0002-2377-2893
Diego MannhartDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0003-0408-8313
Qurrat-Ul-Ain AbidDepartment of Cardiology, Rush Medical Centre, Chicago, IL, USA.ORCID 0000-0001-8156-4817
Andres HöchliDepartment of Cardiology, Triemli Stadtspital, Zürich, Switzerland.
Sorin LazarDepartment of Cardiology, Cook County Health, Chicago, IL, USA.ORCID 0000-0002-7257-6872
Philipp KrisaiDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0002-4367-2363
Arianna Sofia BetteliniDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.
Sven KnechtDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0001-7122-021X
Michael KühneDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0002-2937-3711
Christian SticherlingDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0001-8428-7050
Jeanne du Fay de LavallazDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0002-0806-1786
Patrick BadertscherDepartment of Cardiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID 0000-0001-9751-0557
University Hospital of Basel · CHCook County Health and Hospitals System · USRush University Medical Center · USTriemli Hospital · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPulmonary vein isolation (PVI) plays a central role in the interventional treatment of atrial fibrillation (AF). Uncertainties remain about the durability of ablation lesions from different energy sources. We aimed to systematically review the durability of ablation lesions associated with various PVI-techniques using different energy sources for the treatment of AF. METHODS AND

resultsStructured systematic database search for articles published between January 2010 and January 2023 reporting PVI-lesion durability as evaluated in the overall cohort through repeat invasive remapping during follow-up. Studies evaluating only a proportion of the initial cohort in redo procedures were excluded. A total of 19 studies investigating 1050 patients (mean age 60 years, 31% women, time to remap 2-7 months) were included. In a pooled analysis, 99.7% of the PVs and 99.4% of patients were successfully ablated at baseline and 75.5% of the PVs remained isolated and 51% of the patients had all PVs persistently isolated at follow-up across all energy sources. In a pooled analysis of the percentages of PVs durably isolated during follow-up, the estimates of RFA were the lowest of all energy sources at 71% (95% CI 69-73, 11 studies), but comparable with cryoballoon (79%, 95%CI 74-83, 3 studies). Higher durability percentages were reported in PVs ablated with laser-balloon (84%, 95%CI 78-89, one study) and PFA (87%, 95%CI 84-90, 2 studies).

conclusionWe observed no significant difference in the durability of the ablation lesions of the four evaluated energies after adjusting for procedural and baseline populational characteristics.

Indexed as

Atrial FibrillationCatheter AblationCryosurgeryPulmonary VeinsFemaleHumansMaleMiddle AgedRecurrenceTime FactorsTreatment OutcomeAtrial FibrillationCryoballoon AblationLaser BalloonPulmonary Vein IsolationPulsed-Field AblationRadiofrequency Ablation

Identifiers

PMID37944133
PMCPMC10664405
OpenAlexW4388521672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.