ArticleScience (New York, N.Y.)2023
Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.Hepatology communications · 2026Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol.Emerging microbes & infections · 2026Article
- Dual functions of NPC1L1 for cholesterol transport: Cholesterol capture and regulation of inner-leaflet cholesterol accessibility.iScience · 2026Article
- Design and structural basis of selective nonsteroidal inhibitors of aster cholesterol trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sterol binding mechanism of a plant START-like domain: A new sterol transport paradigm via an amphiphilic cavity.The FEBS journal · 2026Article
- Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo.Acta physiologica (Oxford, England) · 2026Review
- Intestinal Source Control of Lipid Metabolism by Enzyme-Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine-Adhesive Hydrogel Microspheres.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Niemann-Pick C1-Like 1 in Cholesterol Absorption and Homeostasis: Mechanisms, Regulation, and Emerging Phytochemical Inhibitors.Current issues in molecular biology · 2026Review
- Balancing cholesterol metabolism in the liver and gut: perspectives in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Phosphatidylserine transporters ORP5 and ORP8 control cholesterol trafficking from the plasma membrane to the endoplasmic reticulum.Journal of lipid research · 2026Article
- Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes.Military Medical Research · 2025Review
- Review of methods for the determination of cellular cholesterol content: principles, advantages, limitations, applications, and perspectives.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- T cell cholesterol transport links intestinal immune responses to dietary lipid absorption.Science (New York, N.Y.) · 2025Article
- The multimodal transcriptional response of denervated skeletal muscle involves regulation ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Plasma membrane accessible cholesterol is regulated by ACC1 and lipid droplets.bioRxiv : the preprint server for biology · 2025Article
- METTL3 promotes the hypertrophic scar fibrosis via m6A RNA methylation of GRAMD1B mRNA.Journal of molecular histology · 2025Article
- Recent advances in carotenoid absorption, distribution, and elimination.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Review
- Article
- Aster-B Modulates Oxidative Stress Responses and Carotenoid Distribution in ARPE-19 Cells.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
28 authors at 4 institutions in 4 countries.
Alessandra Ferrari *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-7354-9895
Emily Whang *Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0704-6178
Xu XiaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5033-7627
John P KennellyDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-4399-3976
Beatriz Romartinez-AlonsoInstitute for Structural and Chemical Biology, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0002-3061-6696
Julia J MackDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-9239-8436
Thomas WestonDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0003-3720-8633
Kai ChenDepartment of Chemistry, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0001-6850-1723
Youngjae KimDepartment of Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2122-6562
Marcus J TolDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lara BideyanDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8749-6464
Alexander NguyenDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-6578-3454
Yajing GaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8836-4452
Liujuan CuiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-6186-1558
Alexander H BedardDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-9208-398X
Jaspreet SandhuDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Stephen D LeeDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-4663-9534
Louise FairallInstitute for Structural and Chemical Biology, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0001-9456-3047
Kevin J WilliamsDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8091-7924
Wenxin SongDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-6568-4461
Priscilla MunguiaDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Robert A RussellNational Deuteration Facility, Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia.ORCID 0000-0002-6819-8194
Martin G MartinPediatric Gastroenterology, Hepatology, and Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-7192-0504
Michael E JungDepartment of Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1290-8588
Haibo JiangDepartment of Chemistry, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-2384-4826
John W R SchwabeInstitute for Structural and Chemical Biology, University of Leicester, Leicester LE1 7RH, UK.ORCID 0000-0003-2865-4383
Stephen G YoungDepartment of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-7270-3176
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1259-0477
University of California, Los Angeles · USUniversity of Leicester · GBThe University of Western Australia · AUAustralian Nuclear Science and Technology Organisation · AU
Funding
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MCOngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8MUnderstanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7MGASTROENTEROLOGYT32DK007180 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JENSEN, DENNIS MICHAEL · 1986 to 2025
$10.0MInvestigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1MThe Nuclear Receptor-Aster Pathway in Enterohepatic MetabolismR01DK126779 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TONTONOZ, PETER J · 2020 to 2024
$2.4MUCLA Child Health Research Career Development AwardK12HD111040 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sherin U Devaskar, Shafali Spurling Jeste · 2023 to 2026
$1.2MNHLBI NIH HHS P01 HL146358NHLBI NIH HHS R35 HL139725NICHD NIH HHS K12 HD111040NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK126779NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS T32 DK007180
Abstract
Intestinal absorption is an important contributor to systemic cholesterol homeostasis. Niemann-Pick C1 Like 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake, but how cholesterol moves downstream of NPC1L1 is unknown. We show that Aster-B and Aster-C are critical for nonvesicular cholesterol movement in enterocytes. Loss of NPC1L1 diminishes accessible plasma membrane (PM) cholesterol and abolishes Aster recruitment to the intestinal brush border. Enterocytes lacking Asters accumulate PM cholesterol and show endoplasmic reticulum cholesterol depletion. Aster-deficient mice have impaired cholesterol absorption and are protected against diet-induced hypercholesterolemia. Finally, the Aster pathway can be targeted with a small-molecule inhibitor to manipulate cholesterol uptake. These findings identify the Aster pathway as a physiologically important and pharmacologically tractable node in dietary lipid absorption.
Indexed as
Cholesterol, DietaryEnterocytesIntestinal AbsorptionMembrane Transport ProteinsAnimalsBiological TransportHumansJejunumLiver X ReceptorsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutCholesterol, DietaryGRAMD1B protein, humanLiver X ReceptorsMembrane ProteinsMembrane Transport ProteinsNpc1l1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.