Evidence map›Paper›PMID 37943478›Full record

ArticleJournal of neurovirology2023

The relationship between synaptodendritic neuropathology and HIV-associated neurocognitive disorders is moderated by cognitive reserve.

Arin Fisher, David J Moore, Andrew J Levine, Eliezer Masliah, Ben Gouaux, Virawudh Soontornniyomkij, Scott Letendre, Erin E Sundermann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Arin FisherDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA.
Andrew J LevineDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Eliezer MasliahNational Institute On Aging, Bethesda, MD, USA.
Ben GouauxDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA.
Virawudh SoontornniyomkijDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA.
Scott LetendreDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Erin E SundermannDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92037, USA. esundermann@health.ucsd.edu.ORCID 0000-0001-5821-8035
University of California San Diego · USNational Institute on Aging · USUniversity of California, Los Angeles · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH (CHARTER)N01MH22005 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2007 to 2009
$12.0M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
A multi-systems study of HIV neuropathogenesis: genetics-neuropathology-behaviorR01MH096648 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVINE, ANDREW J, MOORE, DAVID J · 2012 to 2016
$1.6M
CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH /CHARTER/ -278022005-278022005N01MH022005 · NIMH · UNIVERSITY OF CA -SAN DIEGO · PI GRANT, IGOR · 2003 to 2006
–
NIDA NIH HHS T32 DA031098NIH HHS N01 MH22005NIH HHS P30 MH062512NIH HHS R01 MH096648NIH HHS T32 DA031098NIH HHS U24 MH100928NIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH096648NIMH NIH HHS U24 MH100928
6 · The paper itself

Abstract

We examined whether cognitive reserve moderated the relationship between neurodegeneration and cognition in 67 postmortem persons with HIV (PWH) who were cognitively assessed within 1 year of death. Cognitive reserve was measured via the Wide Range Achievement Test-4 reading subtest (WRAT4). Synaptodendritic neurodegeneration was based on densities of synaptophysin and microtubule-associated protein 2 immunohistochemical reactivity in frontal cortex, and categorized as minimal, moderate, or severe (tertile-split). T-Scores from 15 cognitive tests were averaged into a global cognitive T-score. Among those with low cognitive reserve (based on WRAT4 median split), the moderate neurodegeneration group showed cognition that was poorer than the minimal neurodegeneration group and comparable to the severe neurodegeneration group. Among those with high cognitive reserve, the moderate neurodegeneration group showed cognition comparable to the minimal neurodegeneration group and better than the severe neurodegeneration group. High cognitive reserve may buffer against cognitive impairment among PWH with moderate, but not severe, neurodegeneration.

Indexed as

Cognitive DysfunctionCognitive ReserveHIV InfectionsCognitionHumansNeuropsychological TestsCognitive reserveHANDHIVNeuropathologyNeuropsychology

Identifiers

PMID37943478
PMCPMC12834392
OpenAlexW4388523469

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.