Evidence map›Paper›PMID 37943391›Full record

ArticleCellular and molecular life sciences : CMLS2023

Tubular TMEM16A promotes tubulointerstitial fibrosis by suppressing PGC-1α-mediated mitochondrial homeostasis in diabetic kidney disease.

Jia-Ling Ji, Jun-Ying Li, Jian-Xiang Liang, Yan Zhou, Cong-Cong Liu, Yao Zhang, Ai-Qing Zhang, Hong Liu, Rui-Xia Ma, Zuo-Lin Li

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jia-Ling Ji *Department of Pediatrics, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jun-Ying Li *Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jian-Xiang LiangDepartment of Ultrasonography, Weifang People's Hospital, Weifang, Shandong, China.
Yan ZhouInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China.
Cong-Cong LiuDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yao ZhangDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ai-Qing ZhangDepartment of Pediatrics, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Hong LiuInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China. jstzliu@sina.com.
Rui-Xia MaDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. anita1685@163.com.
Zuo-Lin LiInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, Jiangsu, China. zuolin_li1990@126.com.ORCID http://orcid.org/0000-0002-6694-8406
Qingdao University · CNZhongda Hospital Southeast University · CNSecond Affiliated Hospital of Nanjing Medical University · CNWeifang People's Hospital · CN

Funding

Basic Research Program of Jiangsu Province BK20200363Natural Science Foundation of Shandong Province ZR2022MH161the National Natural Science Foundation of China 82000648
6 · The paper itself

Abstract

Tubulointerstitial fibrosis (TIF) plays a crucial role in the progression of diabetic kidney disease (DKD). However, the underlying molecular mechanisms remain obscure. The present study aimed to examine whether transmembrane member 16A (TMEM16A), a Ca

Indexed as

Diabetes MellitusDiabetic NephropathiesAnimalsFibrosisHomeostasisMiceMitochondriaIntracellular Cl−Mitochondrial dysfunctionPGC-1αTMEM16ATubulointerstitial fibrosis

Identifiers

PMID37943391
PMCPMC11072291
OpenAlexW4388535986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.