ArticleBrain structure & function2024
Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis.
Article in Brain structure & function, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Independent component analysis of brain network alterations associated with cognitive impairment in coal workers' pneumoconiosis.BMC medical imaging · 2026Article
- Resting-state fMRI reveals immediate hemodialysis-related changes in cognitive function and brain network connectivity in end-stage renal disease.Scientific reports · 2026Article
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
- Predictive model of neurocognitive functioning after acute coronary syndrome. A machine learning approach.Journal of cardiovascular and thoracic research · 2025Article
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11 authors at 2 institutions in 1 country.
Funding
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Abstract
Coronary heart disease (CHD) confers a high risk of cognitive and mental impairments in patients. This study aimed to explore the association of CHD with functional connectivity and topological properties of brain networks. A total of 27 patients with CHD and 44 healthy controls (HCs) participated in this study and underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Intra- and internetwork functional connectivity alterations were explored using independent component analysis in CHD patients. Furthermore, graph theoretical analysis was adopted to assess abnormalities in small-world properties and network efficiency metrics of brain networks. Compared to HCs, CHD patients exhibited increased functional connectivity between the posterior default mode network and posterior visual network, as well as decreased functional connectivity between the left frontoparietal network and auditory network. In terms of graph theoretical analysis, small-world network topology was identified in both CHD patients and HCs. Furthermore, the nodal local efficiency of the left putamen was significantly decreased in CHD patients compared to HCs. This study revealed alterations in brain functional connectivity and topological properties in CHD patients, shedding light on the potential neurological mechanism underlying cognitive and mental impairments in these patients and suggesting unexplored connections between CHD and higher order cognitive processing.
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