Smyd3 negatively regulates the anti-viral pathway by promoting TAK1 degradation in teleost fish.

Zhili Qu, Yuqin Sun, Xuefeng Zhou, Xiaolong Yan, Tianjun Xu

Open access · greenAbstract read

In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.7field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhili Qu *Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.ORCID 0009-0009-4488-6097

Yuqin Sun *Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.ORCID 0009-0006-9782-6109

Xuefeng ZhouLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.

Xiaolong YanLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.

Tianjun XuLaboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University , Shanghai, China.ORCID 0000-0003-3606-8069

Shanghai Ocean University · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

MOST | National Natural Science Foundation of China (NSFC) 31822057

6 · The paper itself

Abstract

importanceIn this study, we have found that the existence of Smyd3 promoted the replication of SCRV. Additionally, we report that Smyd3 negatively regulates the NF-κB and IRF3 signaling pathway by facilitating the degradation of TAK1 in fish. Our findings suggest that Smyd3 interacts with TAK1. Further investigations have revealed that Smyd3 specifically mediates K48-linked ubiquitination of TAK1 and enhances TAK1 degradation, resulting in a significant inhibition of the NF-κB and IRF3 signaling pathway. These results not only contribute to the advancement of fish anti-viral immunity but also provide new evidence for understanding the mechanism of TAK1 in mammals.

Indexed as

Fish DiseasesInterferon Regulatory Factor-3MAP Kinase Kinase KinasesNF-kappa BSignal TransductionAnimalsFishesRhabdoviridaeUbiquitinationInterferon Regulatory Factor-3MAP Kinase Kinase KinasesNF-kappa BIRF3NF-κBSmyd3TAK1ubiquitination

Identifiers

PMID37943055

DOI10.1128/jvi.01306-23

PMCPMC10688333

OpenAlexW4388539931

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.