Evidence map›Paper›PMID 37942948›Full record

ArticlemSystems2023

Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease.

Lola Holcomb, Johanna M Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M Mawe and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Lola Holcomb *Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.
Johanna M Holman *School of Food and Agriculture, University of Maine, Orono, Maine, USA.
Molly HurdLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Brigitte LavoieLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Louisa ColucciDepartment of Biology, Husson University, Bangor, Maine, USA.
Benjamin HuntDepartment of Biology, University of Maine, Orono, Maine, USA.
Timothy HuntDepartment of Biology, University of Maine, Orono, Maine, USA.
Marissa KinneySchool of Food and Agriculture, University of Maine, Orono, Maine, USA.
Jahnavi PathakGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.
Gary M MaweLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Peter L MosesLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Emma PerryElectron Microscopy Laboratory, University of Maine, Orono, Maine, USA.
Allesandra StratigakisSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA.
Tao ZhangSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA.
Grace ChenDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Suzanne L IshaqGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.ORCID 0000-0002-2615-8055
Yanyan LiGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA.ORCID 0000-0002-8139-6718
University of Maine · USUniversity of Vermont · USBinghamton University · USHusson University · USUniversity of Michigan · US

Funding

Harnessing gut microbiota to reduce inflammation using broccoli-sprout dietsR15DK133826 · NIDDK · UNIVERSITY OF MAINE ORONO · PI PELLEGRINI, SUZANNE ISHAQ · 2022 to 2022
$436k
NIDDK NIH HHS R15 DK133826
6 · The paper itself

Abstract

importanceTo our knowledge, IL-10-KO mice have not previously been used to investigate the interactions of host, microbiota, and broccoli, broccoli sprouts, or broccoli bioactives in resolving symptoms of CD. We showed that a diet containing 10% raw broccoli sprouts increased the plasma concentration of the anti-inflammatory compound sulforaphane and protected mice to varying degrees against disease symptoms, including weight loss or stagnation, fecal blood, and diarrhea. Younger mice responded more strongly to the diet, further reducing symptoms, as well as increased gut bacterial richness, increased bacterial community similarity to each other, and more location-specific communities than older mice on the diet intervention. Crohn's disease disrupts the lives of patients and requires people to alter dietary and lifestyle habits to manage symptoms. The current medical treatment is expensive with significant side effects, and a dietary intervention represents an affordable, accessible, and simple strategy to reduce the burden of symptoms.

Indexed as

BrassicaCrohn DiseaseEnterocolitisInflammatory Bowel DiseasesAnimalsDietHumansMice16S rDNACrohn’s diseasecruciferous vegetablesdietary bioactivesglucoraphaningut microbiotainterleukin-10 knockoutsulforaphane

Identifiers

PMID37942948
PMCPMC10734470
OpenAlexW4388527268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.