Evidence map›Paper›PMID 37942469›Full record

ArticleInternational journal of dentistry2023

Osteoclastogenesis Inhibitor and Antioxidant Properties of Konjac Glucomannan in a Periodontitis Mice Model: An In Vivo Study.

Edlyn Dwiputri, Kartika Dhipta Lestari, Geraldi Hartono Kurniawan Tan, Benso Sulijaya, Yuniarti Soeroso, Sri Lelyati C Masulili, Naoki Takahashi, Koichi Tabeta, Fatimah Maria Tadjoedin

Open access · goldAbstract read
In one paragraph

Article in International journal of dentistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Edlyn DwiputriDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Kartika Dhipta LestariDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Geraldi Hartono Kurniawan TanDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Benso SulijayaDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-5976-430X
Yuniarti SoerosoDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0003-4660-3045
Sri Lelyati C MasuliliDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Naoki TakahashiDivision of Periodontology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0001-8952-7260
Koichi TabetaDivision of Periodontology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0002-7019-1872
Fatimah Maria TadjoedinDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.ORCID https://orcid.org/0000-0002-8767-0941
University of Indonesia · IDNiigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Periodontitis is an inflammatory disease caused by specific microorganisms that gradually damage the periodontal and tooth-supporting tissues, thereby reducing a person's quality of life. Periodontal disease is closely associated with high reactive oxygen species (ROS) levels, with a high receptor activator of nuclear factor k Methods: Eight-week-old male Swiss Webster mice were divided into the nonligation, nonligation + KGM, ligation + Results: The periodontitis group pretreated with KGM presented with significantly reduced alveolar bone damage, RANKL/OPG ratio, and ROS level than without KGM group. KGM treatment had no harmful/toxic effects in mice. Conclusion: Administration of KGM could act as an adjunctive in periodontal therapy by suppressing periodontal disease via osteoclastogenesis inhibitory and antioxidant properties.

Identifiers

PMID37942469
PMCPMC10630005
OpenAlexW4388085909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.