ReviewRSC advances2023
Recent achievements in the synthesis of benzimidazole derivatives.
Review in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Synthesis and Characterization of a New Zinc-Coordinated Covalent Organic Polymer: A Versatile Catalyst for the Synthesis of 2-Substituted Benzimidazoles and Quinoline Derivatives.Chemistry, an Asian journal · 2026Article
- A laccase-mediator system based on caffeic acid for the synthesis of benzimidazoles.Scientific reports · 2026Article
- Crystal structure and Hirshfeld surface analysis ofActa crystallographica. Section E, Crystallographic communications · 2026Article
- Electrochemical Synthesis of 1,2-SubstitutedOrganic letters · 2026Article
- Synthesis of benzimidazoles fromRSC advances · 2025Article
- Biologically Active Benzimidazole Hybrids as Cancer Therapeutics: Recent Advances.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Synthesis and SARs of benzimidazoles: insights into antimicrobial innovation (2018-2024).RSC advances · 2025Review
- Synthesis and Evaluation ofLife (Basel, Switzerland) · 2025Article
- Photo-induced decarboxylative radical cascade cyclization of unactivated alkenes: access to CF- and CFRSC advances · 2025Article
- Base-Mediated Synthesis of Imidazole-Fused 1,4-Benzoxazepines via 7-The Journal of organic chemistry · 2025Article
- Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016-2023).Molecular diversity · 2025Review
- Polyoxometalate on functionalized graphene sheets as a hybrid catalyst for efficient synthesis of benzimidazoles.Scientific reports · 2025Article
- Effect of Trichomonacide 6-Nitro-1International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzimidazoles are a class of heterocyclic compounds in which a benzene ring is fused to the 4 and 5 positions of an imidazole ring. Benzimidazole refers to the parent compound, while benzimidazoles are a class of heterocyclic compounds having similar ring structures, but different substituents. Benzimidazole derivatives possess a wide range of bioactivities including antimicrobial, anthelmintic, antiviral, anticancer, and antihypertensive activities. Many compounds possessing a benzimidazole skeleton have been employed as drugs in the market. The application of benzimidazoles in other fields has also been documented. The synthesis of benzimidazole derivatives has attracted much attention from chemists and numerous articles on the synthesis of this class of heterocyclic compound have been reported over the years. The condensation between 1,2-benzenediamine and aldehydes has received intensive interest, while many novel methods have been developed. In this article, we will give a comprehensive review of studies on the synthesis of benzimidazole, which date back to 2013. We have also tried to describe reaction mechanisms as much as we can. The work might be useful for chemists who work in the synthesis of heterocycles or drug chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.