Evidence map›Paper›PMID 37942280›Full record

ArticleJournal of extracellular biology2023

Human red blood cells release microvesicles with distinct sizes and protein composition that alter neutrophil phagocytosis.

Getulio Pereira de Oliveira Junior, Joshua A Welsh, Brandy Pinckney, Cintia C Palu, Shulin Lu, Alan Zimmerman, Raquel Hora Barbosa, Parul Sahu, Maeesha Noshin, Suryaram Gummuluru and 4 more

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Journal of extracellular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. bioRxiv : the preprint server for biology · 2026
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  12. Chronic Stress-Induced and Tumor Derived SP1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Getulio Pereira de Oliveira JuniorDivision of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Joshua A WelshTranslational Nanobiology Section, Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Brandy PinckneyNano Flow Core Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Cintia C PaluTranslational Data Scientist, Sanofi, Cambridge, UK.
Shulin LuDivision of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Alan ZimmermanDepartment of Chemistry and Chemical Biology, Barnett Institute of Chemical & Biological Analysis, Northeastern University, Boston, MA, USA.
Raquel Hora BarbosaDivision of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Parul SahuDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Maeesha NoshinTranslational Nanobiology Section, Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Suryaram GummuluruDepartment of Microbiology, Boston University School of Medicine, Boston, MA, USA.
John TiggesNano Flow Core Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jennifer Clare JonesTranslational Nanobiology Section, Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Alexander R IvanovDepartment of Chemistry and Chemical Biology, Barnett Institute of Chemical & Biological Analysis, Northeastern University, Boston, MA, USA.
Ionita C GhiranDivision of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USNational Cancer Institute · USNortheastern University · USBoston University · USSanofi (France) · FR

Funding

Effect of methodological and biological variability on molecular profiling of extracellular vesicles in cancer detectionR01CA218500 · NCI · NORTHEASTERN UNIVERSITY · PI GHIRAN, IONITA CALIN, IVANOV, ALEXANDER R. · 2018 to 2022
$4.0M
Robust ultra-high sensitivity proteomic technologies for limited samplesR35GM136421 · NIGMS · NORTHEASTERN UNIVERSITY · PI Alexander R. Ivanov · 2020 to 2026
$3.4M
Bioengineered red blood cells as extracellular vesicle-mediated delivery platforms for gene editing machineryUG3HL147353 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN · 2018 to 2020
$2.4M
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and CardiomyopathyR01HL156116 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEL MONTE, FEDERICA, GHIRAN, IONITA CALIN · 2021 to 2024
$2.0M
Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometryUH3TR002881 · NCATS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN, JONES, JENNIFER · 2021 to 2022
$1.9M
Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometryUG3TR002881 · NCATS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GHIRAN, IONITA CALIN, JONES, JENNIFER · 2019 to 2020
$816k
NCATS NIH HHS UG3 TR002881NCATS NIH HHS UH3 TR002881NCI NIH HHS R01 CA218500NHLBI NIH HHS R01 HL156116NHLBI NIH HHS UG3 HL147353NIGMS NIH HHS R35 GM136421
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membrane-bound structures released by cells and tissues into biofluids, involved in cell-cell communication. In humans, circulating red blood cells (RBCs), represent the most common cell-type in the body, generating daily large numbers of microvesicles.

Indexed as

calcium ionophoresExtracellular vesiclesneutrophilsRBCs

Identifiers

PMID37942280
PMCPMC10629908
OpenAlexW4387932267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.