ArticleBrain communications2023
Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.
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Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adults.medRxiv : the preprint server for health sciences · 2026Article
- Behavior of neural networks in culture suggest that sporadic and genetic forms of Alzheimer's disease may not be equivalent.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease.Science advances · 2025Article
- Insights into insulin signalling and oxidative stress in the Tg2576 mouse model of familial Alzheimer's disease: effects of chronic oral galactose administration.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- A unique subpopulation of wild-type neurons recapitulating familial Alzheimer's disease phenotypes.Cell death & disease · 2025Article
- Early increase of the synaptic blood marker β-synuclein in asymptomatic autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review.Molecular biology reports · 2025Review
- The early-onset Alzheimer's disease MRI signature: a replication and extension analysis in early-stage AD.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Deciphering the Morphological Difference of Amyloid-β Fibrils in Familial and Sporadic Alzheimer's Diseases.Journal of chemical information and modeling · 2024Article
- Clinical and research application of fluid biomarkers in autosomal dominant Alzheimer's disease and Down syndrome.EBioMedicine · 2024Review
- Melatonin Supplementation Alleviates Impaired Spatial Memory by Influencing AβInternational journal of molecular sciences · 2024Article
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2024Article
- Hand motor function of patients with early- and late-onset Alzheimer's disease and its relation to activities of daily living.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
42 authors at 10 institutions in 5 countries.
Jorge J Llibre-GuerraDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.ORCID https://orcid.org/0000-0002-2137-7750
Leonardo IaccarinoDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Dean CobleDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Lauren EdwardsDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Yan LiDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Eric McDadeDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.
Amelia StromDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Brian GordonMalinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO 63108, USA.ORCID https://orcid.org/0000-0003-2109-2955
Nidhi MundadaDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Suzanne E SchindlerDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.
Elena TsoyDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Yinjiao MaDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Ruijin LuDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Anne M FaganDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.
Tammie L S BenzingerMalinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO 63108, USA.
David Soleimani-MeigooniDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0003-4197-3039
Andrew J AschenbrennerDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.ORCID https://orcid.org/0000-0002-4317-7282
Zachary MillerDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-5991-3053
Guoqiao WangDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Joel H KramerDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Jason HassenstabDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.
Howard J RosenDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
John C MorrisDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.ORCID https://orcid.org/0000-0003-2967-9662
Bruce L MillerDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Chengjie XiongDivision of Biostatistics, Washington University in St Louis, St Louis, MO 63108, USA.
Richard J PerrinDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.
Ricardo AllegriDepartment of Cognitive Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina.
Patricio ChremDepartment of Cognitive Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina.
Ezequiel SuraceDepartment of Cognitive Neurology, Institute for Neurological Research Fleni, Buenos Aires, Argentina.
Sarah B BermanDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jasmeer ChhatwalMassachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-7792-1698
Colin L MastersFlorey Institute, The University of Melbourne, Melbourne 3052, Australia.ORCID https://orcid.org/0000-0003-3072-7940
Martin R FarlowNeuroscience Center, Indiana University School of Medicine at Indianapolis, IN 46202, USA.
Mathias JuckerDZNE-German Center for Neurodegenerative Diseases, Tübingen 72076, Germany.
Johannes LevinDepartment of Neurology, Ludwig-Maximilians-University, Munich 80539, Germany.ORCID https://orcid.org/0000-0001-5092-4306
Nick C FoxDementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London WC1N 3BG, UK.
Gregory DayDepartment of Neurology, Mayo Clinic Florida, Jacksonville, FL 33224, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Adam L BoxerDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Renaud La JoieDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0003-2581-8100
Gil D RabinoviciDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Randall BatemanDepartment of Neurology, Washington University in St Louis, St Louis, MO 63108, USA.ORCID https://orcid.org/0000-0002-7729-1702
Washington University in St. Louis · USUniversity of California, San Francisco · USInstituto de Neurología Cognitiva · ARGerman Center for Neurodegenerative Diseases · DEHarvard University · USIndiana University School of MedicineMayo Clinic in Florida · USThe University of Melbourne · AUUK Dementia Research Institute · GBUniversity of Pittsburgh · US
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Serggio Carlo Lanata · 2019 to 2026
$36.9MDIAN-TU Next Generation Prevention Trial - Data Request Management SupplementR01AG053267 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2017 to 2023
$34.9MProgressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0MReimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8MEarly Age-of-Onset AD: Clinical Heterogeneity and Network DegenerationR01AG045611 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RABINOVICI, GIL DAN · 2014 to 2018
$3.1MUnderstanding Alzheimer disease heterogeneity in Hispanic populations.K01AG073526 · NIA · WASHINGTON UNIVERSITY · PI Jorge Jesus Llibre-Guerra · 2022 to 2026
$511kConnectome-based spread of neurodegenerative processes in Alzheimer's diseaseK99AG065501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LA JOIE, RENAUD CHARLES · 2020 to 2021
$253kNIA NIH HHS K01 AG073526NIA NIH HHS K99 AG065501NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG045611NIA NIH HHS R01 AG053267NIA NIH HHS R35 AG072362NIA NIH HHS U19 AG032438NINDS NIH HHS R01 NS050915
Abstract
Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent to which dominantly inherited and sporadic early-onset Alzheimer's disease overlap is unknown. In this study, we explored the clinical, cognitive and biomarker profiles of early-onset Alzheimer's disease, focusing on commonalities and distinctions between dominantly inherited and sporadic cases. Our analysis included 117 participants with dominantly inherited Alzheimer's disease enrolled in the Dominantly Inherited Alzheimer Network and 118 individuals with sporadic early-onset Alzheimer's disease enrolled at the University of California San Francisco Alzheimer's Disease Research Center. Baseline differences in clinical and biomarker profiles between both groups were compared using
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dominantly inheritedearly-onset Alzheimer’s diseasesporadic
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