Evidence map›Paper›PMID 37942066›Full record

ArticleFrontiers in cardiovascular medicine2023

Smooth muscle cells-specific loss of OCT4 accelerates neointima formation after acute vascular injury.

Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K Owens, Olga A Cherepanova

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Junchul ShinDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Svyatoslav TkachenkoDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, United States.
Delphine GomezDepartment of Medicine, Division of Cardiology, University of Pittsburgh, Pittsburgh, PA, United States.
Rupande TripathiRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States.
Gary K Owens *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States.
Olga A Cherepanova *Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Cleveland Clinic Lerner College of Medicine · USUniversity of Virginia · USCase Western Reserve University · USUniversity of Pittsburgh · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Epigenetic control of smooth muscle cell phenotype during microvascular remodelingR01HL146465 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Delphine Gomez · 2019 to 2026
$3.4M
Defining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0M
Role of the TLR4 signaling in smooth muscle cell phenotypic transitionR01HL150193 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEREPANOVA, OLGA · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL146465NHLBI NIH HHS R01 HL150193NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

Introduction: There is growing evidence that smooth muscle cell ( Methods and Results: Here, using an Conclusion: These results demonstrate that the pluripotency factor OCT4 is quickly activated in SMC after the acute vascular injury and inhibits SMC hyperproliferation, which may be protective in preventing excessive neointima formation.

Indexed as

differentiationOCT4proliferationsmooth muscle cellsvascular injury

Identifiers

PMID37942066
PMCPMC10627795
OpenAlexW4387869368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.