ArticleiScience2023
Effects of hepatic mitochondrial pyruvate carrier deficiency on
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Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis.Trends in endocrinology and metabolism: TEM · 2026Review
- Hyperpolarized [U-ACS chemical biology · 2026Article
- The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment.Molecular metabolism · 2025Review
- Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier.European journal of medicinal chemistry · 2025Article
- Sex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier.bioRxiv : the preprint server for biology · 2024Article
- Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.Cell metabolism · 2024Article
- Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
- Update of
Authors and funding
13 authors at 2 institutions in 1 country.
Nicole K H YiewDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Stanislaw DejaCenter for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA.
Daniel FergusonDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Kevin ChoDepartment of Chemistry, Siteman Cancer Center, Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63110, USA.
Chaowapong JarasvaraparnDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Miriam Jacome-SosaDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Andrew J LutkewitteDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Sandip MukherjeeDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Xiaorong FuCenter for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA.
Jason M SingerDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Gary J PattiDepartment of Chemistry, Siteman Cancer Center, Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63110, USA.
Shawn C BurgessCenter for Human Nutrition, University of Texas Southwestern, Dallas, TX 75390, USA.
Brian N FinckDepartment of Medicine, Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.
Washington University in St. Louis · USThe University of Texas Southwestern Medical Center · US
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Rodney D Newberry · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Nada A. Abumrad · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MDIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MTARGETING THE MITOCHONDRIAL PYRUVATE CARRIER TO TREAT NONALCOHOLIC STEATOHEPATITISR01DK104735 · NIDDK · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2015 to 2025
$7.1MFactors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8MDeveloping Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9MRegulation of lipogenesis by TCA cycle metabolismR01DK128168 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2021 to 2025
$2.1MNOVEL ASPECTS OF HEPATIC MITOCHONDRIAL AMINO ACID METABOLISMR01DK117657 · NIDDK · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2018 to 2022
$1.9MTraining in Integrative and Systems Biology of Cardiovascular DiseaseT32HL134635 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2017 to 2021
$1.8MMacrophage Mitochondrial Pyruvate Carrier in Nonalcoholic SteatohepatitisK01DK137050 · NIDDK · WASHINGTON UNIVERSITY · PI Daniel Ferguson · 2023 to 2026
$539kNHLBI NIH HHS T32 HL134635NIDDK NIH HHS K01 DK126990NIDDK NIH HHS K01 DK133630NIDDK NIH HHS K01 DK137050NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK104735NIDDK NIH HHS R01 DK117657NIDDK NIH HHS R01 DK128168NIDDK NIH HHS T32 DK007120NIEHS NIH HHS R35 ES028365
Abstract
The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via
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Cellular physiologyHuman metabolism
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.