Evidence map›Paper›PMID 37941832›Full record

ArticleMolecular therapy. Nucleic acids2023

Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic

Chandran Sivasankar, Chamith Hewawaduge, Pandiyan Muthuramalingam, John Hwa Lee

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Transforming bacterial pathogens into wonder tools in cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Bacterial live therapeutics for human diseases.Molecular systems biology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chandran SivasankarCollege of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.
Chamith HewawadugeCollege of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.
Pandiyan MuthuramalingamDepartment of GreenBio Science, Gyeongsang National University, Jinju 52725, South Korea.
John Hwa LeeCollege of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea.
Jeonbuk National University · KRGyeongsang National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging chemo- and radiotherapy resistance exacerbated the cancer risk and necessitated novel treatment strategies. Although RNA therapeutics against pro-oncogenic genes are highly effective, tumor-specific delivery remains a barrier to the implementation of this valuable tool. In this study, we report a tryptophan-auxotrophic

Indexed as

4T1 breast cancerantisense-RNAanti-tumor effectMT: delivery strategiesRCAS1Salmonella deliverytryptophan-auxotrophtumor specificity

Identifiers

PMID37941832
PMCPMC10628790
OpenAlexW4387613541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.