Evidence map›Paper›PMID 37941765›Full record

ReviewCerebral circulation - cognition and behavior2023

A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.

Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall and 47 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cerebral circulation - cognition and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Targeting Neurovascular Pathways: Gene Therapy as a Novel Treatment for Vascular Dementia After Stroke.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Editorial.Cerebral circulation - cognition and behavior · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

57 authors.

Sarmi SriUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
Adam GreensteinDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
Alessandra GranataDepartment of Clinical Neurosciences, Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0BB, UK.
Alex CollcuttUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
Angela C C JochemsCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Barry W McCollUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Blanca Díaz CastroUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Caleb WebberUK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UK.
Carmen Arteaga ReyesCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Catherine HallSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UK.
Catherine B LawrenceGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Cheryl HawkesBiomedical and Life Sciences, Lancaster University, Lancaster, UK.
Chrysia-Maria Pegasiou-DaviesUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
Claire GibsonSchool of Psychology, University of Nottingham, Nottingham NG7 2UH, UK.
Colin L CrawfordUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Colin SmithCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Denis VivienPhysiopathology and Imaging of Neurological Disorders (PhIND), Normandie University, UNICAEN, INSERM UMR-S U1237, , GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
Fiona H McLeanDivision of Systems Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.
Frances WisemanUK Dementia Research Institute, University College London, London WC1N 3BG, UK.
Gaia BrezzoUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Giovanna LalliUK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
Harry A T PritchardDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
Hugh S MarkusStroke Research Group, Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
Isabel Bravo-FerrerUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Jade TaylorDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
James LeiperBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Jason BerwickDepartment of Psychology, University of Sheffield, Sheffield, UK.
Jian GanUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
John GallacherDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Jonathan MossUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Jozien GoenseNeuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Letitia McMullanSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UK.
Lorraine WorkSchool of Cardiovascular & Metabolic Health, College of Medical, Veterinary & Life Sciences, University of Glasgow; Glasgow; UK.
Lowri EvansDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
Michael S StringerCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Mlj AshfordDivision of Systems Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.
Mohamed AbulfadlDementia Research Group, Department of Clinical Neurosciences, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UK.
Nina ConlonDivision of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
Paresh MalhotraDepartment of Brain Sciences, Imperial College London, London, UK.
Philip BathStroke Trials Unit, University of Nottingham, Nottingham, UK; Stroke, Medicine Division, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Rebecca CanterDementia Discovery Fund, SV Health Managers LLP, London, UK.
Rosalind BrownUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Selvi InceDementia Research Group, Department of Clinical Neurosciences, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UK.
Silvia AnderleSchool of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UK.
Simon YoungDementias Platform UK, Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.
Sophie QuickUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Stefan SzymkowiakCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Steve HillCentre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
Stuart AllanGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Tao WangGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Terry QuinnCollege of Medical Veterinary and Life Sciences, University of Glasgow, Scotland, UK.
Tessa ProcterUK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
Tracy D FarrSchool of Life Sciences, Physiology, Pharmacology, and Neuroscience Division, Medical School, University of Nottingham, Nottingham NG7 2UH, UK.
Xiangjun ZhaoDivision of Evolution, Infection and Genomic Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, UK.
Zhiyuan YangDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.
Atticus H HainsworthMolecular and Clinical Sciences Research Institute, St George's University of London SW17 0RE, UK.
Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Funding

British Heart Foundation PG/20/10397British Heart Foundation SP/F/22/150042Chief Scientist Office CZB/4/517Medical Research Council MR/L003384/1Medical Research Council MR/T033371/1Medical Research Council MR/X003418/1National Centre for the Replacement, Refinement and Reduction of Animals in Research G0800701/1
6 · The paper itself

Abstract

Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

Indexed as

Cerebral vascular diseaseDementiaSmall vessel diseaseVascular cognitive impairmentVascular dementia

Identifiers

PMID37941765
PMCPMC10628644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.