Evidence map›Paper›PMID 37941082›Full record

ArticleLaboratory animal research2023

Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation.

Yi-Chih Chang, Hao-Ping Liu, Hsiao-Li Chuang, Jiunn-Wang Liao, Pei-Ling Kao, Hsun-Lung Chan, Ter-Hsin Chen, Yu-Chih Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory animal research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yi-Chih Chang *Department of Medical Laboratory Science & Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.
Hao-Ping Liu *Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
Hsiao-Li Chuang *National Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan.
Jiunn-Wang LiaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan.
Pei-Ling KaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan.
Hsun-Lung ChanVeterinary Research Institute, Ministry of Agriculture, Zhunan, Taiwan.
Ter-Hsin ChenGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan.
Yu-Chih WangGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 40227, Taiwan. ycw2017@email.nchu.edu.tw.ORCID http://orcid.org/0000-0003-0144-1388
National Chung Hsing University · TWAsia University · TWNational Institutes of Applied Research · TW

Funding

Ministry of Science and Technology of Taiwan MOST-107-2311-B-005 -011 -MY3.Ministry of Science and Technology of Taiwan MOST-110-2313-B-005 -047Ministry of Science and Technology of Taiwan MOST-111-2313-B-005 -035 -MY3
6 · The paper itself

Abstract

backgroundFeline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about 25% of FMC patients. However, the mechanism underlying hepatic metastasis of FMC remains largely uncharacterized.

resultsHerein, we demonstrate that FMC-derived extracellular vesicles (FMC-EVs) promotes the liver metastasis of FMC by activating hepatic stellate cells (HSCs) to prime a hepatic premetastatic niche (PMN). Moreover, we provide evidence that sphingosine kinase 1 (SK1) delivered by FMC-EV was pivotal for the activation of HSC and the formation of hepatic PMN. Depletion of SK1 impaired cargo sorting in FMC-EV and the EV-potentiated HSC activation, and abolished hepatic colonization of FMC cells.

conclusionsTaken together, our findings uncover a previously uncharacterized mechanism underlying liver-metastasis of FMC and provide new insights into prognosis and treatment of this feline malignancy.

Indexed as

Extracellular vesicleFeline mammary carcinomaHepatic stellate cellPre-metastatic nicheSphingosine kinase-1

Identifiers

PMID37941082
PMCPMC10634095
OpenAlexW4388537238

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.