ArticleJournal of biological engineering2023
Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition.
Article in Journal of biological engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Pre-Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Deer antler stem cell-derived exosomes: a regenerative medicine powerhouse from nature's own repair kit.Frontiers in cell and developmental biology · 2026Review
- Application of stem cell-derived exosomes in skin wound healing: mechanisms, prospects, and challenges.Frontiers in immunology · 2026Review
- Gift of nature: non-human-derived exosomes showing application prospects in periodontitis treatment.Frontiers in immunology · 2026Review
- Modern Advances in Velvet Antler Research: From Identification Methods to Pharmacological Mechanisms.International journal of food science · 2026Review
- Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing.Scientific reports · 2025Article
- Deer antler ASCs exosomes ameliorate osteoarthritis via miR-140/MMP13 axis-mediated dual modulation of inflammation and cartilage regeneration.NPJ Regenerative medicine · 2025Article
- Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis.Cell death discovery · 2025Article
- Local and systemic factors both required for full renewal of deer antlers, and systemic factors only for generic cutaneous regenerative healing.Cell regeneration (London, England) · 2025Review
- Advancements in Stem Cell Applications for Livestock Research: A Review.Veterinary sciences · 2025Review
- Dual-network hydrogel loaded with antler stem cells conditioned medium and EGCG promotes diabetic wound healing through antibacterial, antioxidant, anti-inflammatory, and angiogenesis.Materials today. Bio · 2025Article
- Systemic factors associated with antler growth promote complete wound healing.NPJ Regenerative medicine · 2025Article
- Optimizing protein yield from growing deer antlers.Frontiers in bioengineering and biotechnology · 2025Article
- Diverse-Origin Exosomes Therapeutic Strategies for Diabetic Wound Healing.International journal of nanomedicine · 2025Review
- Exosomes from Different Sources in Promoting Wound Healing.Recent advances in drug delivery and formulation · 2025Review
- Characteristics and Differences in the Antler Velvet Microbiota During Regeneration.Microorganisms · 2024Article
- Therapeutic applications of stem cell-derived exosomes in radiation-induced lung injury.Cancer cell international · 2024Review
- Deer antler stem cell niche: An interesting perspective.World journal of stem cells · 2024Article
- Deer antler stem cells immortalization by modulation of hTERT and the small extracellular vesicles characters.Frontiers in veterinary science · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionThe typical outcome of mammalian wound healing is scarring, a fibrotic process mediated by myofibroblast aggregation. Perfect healing in a clinical setting is relatively unexplored. Surprisingly, our previous studies have shown that the large wound (10 cm diameter or more) of the pedicle of deer naturally achieves regenerative restoration, realized through a paracrine pathway from adjacent antler stem cells (AnSCs).
methodsAnSC-derived exosomes (AnSC-exos) were topically injected around the full-thickness wounds in a rat model. The effects on the rate of wound healing and the quality of healing were evaluated via morphological, histological, and molecular biological techniques on days 14 and 28 after surgery.
resultsThe results showed that AnSC-exos significantly accelerated the rate of wound healing and improved healing quality, including regeneration of cutaneous appendages (hair follicles and sebaceous glands) and the distribution pattern of collagen (basket-weave-like) in the healed skin. These effects of AnSC-exos were comparable to those of AnSCs but were significantly more potent than those of exosomes derived from bone marrow mesenchymal stem cells (bMSC-exos). Furthermore, AnSC-exos treatment effectively inhibited fibroblast-to-myofibroblast transition (FMT), as evidenced by the reduction of full-thickness skin injury-induced FMT in vivo and TGF-β1-induced FMT in vitro.
conclusionAnSC-exos could effectively promote regenerative cutaneous wound healing, highly likely through FMT inhibition. This suggests that AnSC-exos treatment could provide the potential for a novel approach to induce regenerative wound healing in the clinical setting.
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