ArticleAnnals of clinical microbiology and antimicrobials2023
Unveiling the etiology of peritonsillar abscess using next generation sequencing.
Article in Annals of clinical microbiology and antimicrobials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Peritonsillitis in primary care: patient characteristics and care pathways - a population-based registry study.BMC primary care · 2026Article
- The microbiological spectrum and clinical course of adolescents and adults with peritonsillar abscesses.Scientific reports · 2026Article
- Oropharyngeal Microbiota Associated with Sore Throat in Acute Upper Respiratory Tract Infections.Current microbiology · 2026Article
- Comparative Clinical Outcomes of Needle Aspiration and Incision & Drainage in Peritonsillar Abscess.Journal of clinical medicine · 2026Article
- Taxonomy, carcinogenic mechanisms, and advanced molecular diagnosis of Fusobacterium nucleatum in colorectal cancer: from bench to clinical practice.Frontiers in immunology · 2026Review
- Next-generation sequencing of the tonsillar microbiome in severe acute tonsillitis: comparison with healthy controls and culture-based findings.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- The role of dental status in the pathogenesis and severity of peritonsillar and cervical infections.Frontiers in medicine · 2025Article
- Rapid diagnosis of Lemierre's syndrome by metagenomic next-generation sequencing: a case report.Frontiers in medicine · 2025Article
- Ten-Year Trends in Otolaryngological Surgery Volumes and the Impact of Infection Prevention During the COVID-19 Pandemic-A National Study.Journal of clinical medicine · 2024Article
- Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis.Signal transduction and targeted therapy · 2024Article
- The first case report: diagnosis and management of necrotizing fusobacterium lung abscess via BALF next-generation sequencing.BMC infectious diseases · 2024Article
- Unveiling the dark side ofFrontiers in medicine · 2024Article
- Reexamining the role ofGut microbesReview
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Authors and funding
10 authors.
Funding
Abstract
backgroundPeritonsillar abscess (PTA) is a severe deep neck space infection with an insufficiently characterized bacterial etiology. We aimed to reveal the bacteria associated with PTA applying next generation sequencing (NGS). Tonsil biopsies and pus samples of 91 PTA patients were analysed applying NGS method.
resultsOver 400 genera and 800 species belonging to 34 phyla were revealed. The most abundant species in both sample types were Streptococcus pyogenes, Fusobacterium necrophorum and Fusobacterium nucleatum. When present, S. pyogenes was normally a predominant species, although it was recovered as a minor population in some samples dominated by F. nucleatum and occasionally F. necrophorum. S. pyogenes and F. necrophorum were the predominant species (> 10% in a community) in 28 (31%) pus samples, while F. nucleatum in 21 (23%) and S. anginosus in 8 (9%) pus samples. We observed no substantial differences between the microbial findings in pus and tonsil biopsies.
conclusionsThe most probable causative agents of PTA according to our NGS-study include Streptococcus pyogenes, Fusobacterium necrophorum and Fusobacterium nucleatum. Some other streptococci (S. anginosus) and anaerobes (Prevotella, Porphyromonas) may contribute to the infection as well. Pus of the peritonsillar abscess is more representative specimen for microbiological examination than the tonsillar tissue. Our results are important in the context of optimizing the handling of the PTA patients.
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