Evidence map›Paper›PMID 37940866›Full record

SynthesisBMC infectious diseases2023

Diabetes mellitus and latent tuberculosis infection: an updated meta-analysis and systematic review.

Guozhong Zhou, Xin Guo, Shunli Cai, Yu Zhang, Yuanyuan Zhou, Rong Long, Yingchen Zhou, Hanse Li, Nan Chen, Chao Song

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. A QuantiFERONInfection and drug resistance · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Guozhong Zhou *Department of Science and Research, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China.
Xin Guo *School of Basic Medical Sciences, Kunming Medical University, Kunming, 650051, Yunnan Province, China.
Shunli CaiSchool of Basic Medical Sciences, Kunming Medical University, Kunming, 650051, Yunnan Province, China.
Yu ZhangDepartment of Endocrinology, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China.
Yuanyuan ZhouDepartment of Endocrinology and Metabolism, Sixth Affliated Hospital of Kunming Medical University, The People's Hospital of Yuxi City, Yunnan Province, Yuxi, 653100, China.
Rong LongDepartment of Endocrinology, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China.
Yingchen ZhouThe School of Medicine, Kunming University, Kunming, 650214, China.
Hanse LiSchool of Basic Medical Sciences, Kunming Medical University, Kunming, 650051, Yunnan Province, China.
Nan ChenDepartment of Endocrinology, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China. saint0728@163.com.
Chao SongDepartment of Medical Imaging, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China. chaoge6870@163.com.
Kunming Medical University · CNKunming University of Science and Technology · CNFirst People's Hospital of Yunnan Province · CNKunming University · CN

Funding

Talent Project of Kunming Health Science and Technology 2022-SW [Leading Talents]-001the Scientific Research Project of Kunming Health Commission 2022-03-06-005the Special Project "Spring City Plan" Famous Doctor C202012016the Talent Project of Kunming Health Science and Technology 2022-SW [Reserve]-001
6 · The paper itself

Abstract

backgroundPrevious studies have demonstrated an association between diabetes mellitus (DM) and latent tuberculosis infection (LTBI). This study was conducted to update the current understanding of the association between DM and LTBI. By conducting a systematic review and meta-analysis using adjusted odds ratios (aOR) or risk ratios (aRR), we aimed to further explore the association between DM and LTBI and provide essential reference for future research.

methodsWe conducted comprehensive searches in Embase, Cochrane Library, and PubMed without imposing any start date or language restrictions, up to July 19, 2022. Our study selection encompassed observational research that compared from LTBI positive rates in both DM and non-DM groups and reported aRR or aOR results. The quality of the included studies was assessed utilizing the Newcastle-Ottawa Scale. Pooled effect estimates were calculated using random-effects models, along with their associated 95% confidence intervals (CI).

resultsWe included 22 studies involving 68,256 subjects. Three cohort studies were eligible, with a pooled aRR of 1.26 (95% CI: 0.71-2.23). Nineteen cross-sectional studies were eligible, with a pooled aOR of 1.21 (95% CI: 1.14-1.29). The crude RR (cRR) pooled estimate for three cohort studies was 1.62 (95% CI: 1.03-2.57). Among the cross-sectional studies we included, sixteen studies provided crude ORs, and the crude OR (cOR) pooled estimate was 1.64 (95% CI: 1.36-1.97). In the diagnosis of diabetes, the pooled aOR of the HbA1c group was higher than that of self-reported group (pooled aOR: 1.56, 95% CI: 1.24-1.96 vs. 1.17, 95% CI: 1.06-1.28).

conclusionOur systematic review and meta-analysis suggest a positive association between DM and LTBI. Individuals with DM may have a higher risk of LTBI compared to those without DM. These findings provide important insights for future research and public health interventions in managing LTBI in diabetic populations.

Indexed as

Diabetes MellitusLatent TuberculosisCohort StudiesCross-Sectional StudiesHumansObservational Studies as TopicRisk FactorsTuberculin TestDiabetes mellitusLatent tuberculosis infectionMeta-analysis

Identifiers

PMID37940866
PMCPMC10631079
OpenAlexW4388513695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.