SynthesisLangenbeck's archives of surgery2023
Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.
Synthesis in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Incidence rate of hemorrhagic fever with renal syndrome complicated with acute pancreatitis: a meta-analysis.Frontiers in medicine · 2024Pooled it
- Global practices and attitudes in acute appendicitis management: the PAMAP-W international survey and Delphi consensus study on the WSES appendicitis grading system.World journal of emergency surgery : WJES · 2026Article
- Beyond Appendicitis: A Retrospective Study Predicting Appendiceal Neoplasms in the Era of Non-Operative Management in Jamaica.Journal of racial and ethnic health disparities · 2026Article
- High-grade appendiceal mucinous neoplasm: case report.Journal of surgical case reports · 2026Article
- Incidental appendiceal neoplasms in patients undergoing appendectomy for acute appendicitis: a 10-year retrospective analysis of 5001 cases.Surgical endoscopy · 2026Article
- Low-Grade Appendiceal Mucinous Neoplasm Presenting as an Appendiceal Mucocele: A Case Report.Cureus · 2026Article
- True Incidence of Appendiceal Neoplasms in Patients Presenting with Complicated Appendicitis: A Call for a Revised Management Algorithm.Annals of surgical oncology · 2026Article
- Incidental serrated lesions of the appendix: analysis of 2,137 appendectomy specimens.Journal of pathology and translational medicine · 2026Article
- The risk of neoplasms in appendiceal abscess: what emergency surgeons should know.Frontiers in oncology · 2026Review
- Late Pulmonary and Lymph Node Recurrence 14 Years after Curative Resection of Incidentally Diagnosed Appendiceal Adenocarcinoma with Hepatic Metastasis.Surgical case reports · 2026Article
- Preoperative differentiation of acute appendicitis using NLR, SII, and maximum appendiceal diameter: a retrospective single-center diagnostic study.Frontiers in surgery · 2026Article
- Advanced Computational Modeling and Machine Learning for Risk Stratification, Treatment Optimization, and Prognostic Forecasting in Appendiceal Neoplasms.Healthcare (Basel, Switzerland) · 2025Article
- Preoperative lymphocyte-to-monocyte ratio and CT-measured appendix diameter in occult appendiceal neoplasms: a matched case-control analysis.BMC surgery · 2025Article
- Clinicopathological Profile and Management of Appendiceal Neoplasm: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Evidence-based, cost-effective management of acute appendicitis: An algorithm of the Journal of Trauma and Acute Care Surgery emergency general surgery algorithms work group.The journal of trauma and acute care surgery · 2025Article
- The incidence of incidental neoplasia in pathology samples of patient who underwent appendectomy due to acute appendicitis. A single center experience: 6446 cases.Irish journal of medical science · 2024Article
- Treatment of appendiceal neuroendocrine tumour: a controversial treatment for a misunderstood neoplasm in a mysterious organ.Translational cancer research · 2024Article
- Acute Appendicitis in the Elderly: A Nationwide Retrospective Analysis.Journal of clinical medicine · 2024Article
- Incidental High-Grade Appendiceal Mucinous Neoplasm.CRSLS : MIS case reports from SLSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStudies evaluating the rate and histology of appendiceal neoplasms between complicated and uncomplicated appendicitis include a small number of patients. Therefore, we sought a meta-analysis and systematic review comparing the rates and types of appendiceal neoplasm between complicated and uncomplicated appendicitis.
methodsWe included articles published from the time of inception of the datasets to September 30, 2022. The electronic databases included English publications in Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid EMBASE, and Scopus.
resultsA total of 4962 patients with appendicitis enrolled in 4 comparative studies were included. The mean age was 43.55 years (16- 94), and half were male (51%). Based on intra-operative findings, 1394 (38%) had complicated appendicitis, and 3558 (62%) had uncomplicated appendicitis. The overall incidence rate of neoplasm was 1.98%. No significant difference was found in the incidence rate of appendiceal neoplasm between complicated (3.29%) and uncomplicated (1.49%) appendicitis (OR 0.44, 95% CI 0.16- 1.23; p < 0.087; I2 = 54.9%). The most common appendiceal neoplasms were Neuroendocrine Tumors (NET) (49.21%), Nonmucinous Adenocarcinoma (24.24%), Mixed Adeno-Neuroendocrine Tumor (MANEC) (11.40%), Mucinous Adenocarcinoma (4.44%). There was a significant difference between complicated and uncomplicated appendicitis in rates of adenocarcinoma (50% vs. 13%), NET (31% vs. 74%), MANEC (19% vs. 13%) (P < 0.001).
conclusionWhile there was no significant difference in the overall neoplasm rate between complicated and uncomplicated appendicitis, the NET rate was significantly higher in uncomplicated appendicitis. In comparison, the Adenocarcinoma rate was considerably higher in Complicated appendicitis. These findings emphasize the importance of evaluating risk factors for neoplasm when considering appendectomy in patients with appendicitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.