Evidence map›Paper›PMID 37940765›Full record

ArticleEndocrine2024

The value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation for detecting papillary thyroid carcinoma in cytologically indeterminate thyroid nodules.

Yu Lin, Yiming Cheng, Yan Zhang, Xiuyun Ren, Jie Li, Huaiyin Shi, Yuxin Li, Yukun Luo, Hongwei Wang

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Do thyroid nodules in the isthmus carry a higher risk of malignancy? A systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yu LinDepartment of Pathology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yiming ChengMedical School of Chinese PLA, Beijing, China.
Yan ZhangDepartment of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Xiuyun RenDepartment of Ultrasound, Hainan Hospital, Chinese PLA General Hospital, Sanya, China.
Jie LiDepartment of Pathology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Huaiyin ShiDepartment of Pathology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yuxin LiDepartment of Pathology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yukun LuoDepartment of Ultrasound, The First Medical Center, Chinese PLA General Hospital, Beijing, China. lyk301@163.com.
Hongwei WangDepartment of Pathology, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. whw6626@sina.com.ORCID 0000-0003-2319-3450
Chinese PLA General Hospital · CN

Funding

other projects by the Beijing municipal science and technology commission Z221100003522001
6 · The paper itself

Abstract

purposeTo investigate the value of Korean, American, and Chinese ultrasound risk stratification systems combined with BRAF(V600E) mutation in the detection of papillary thyroid carcinoma (PTC)within cytologically indeterminate thyroid nodules (CITNs).

methodsA single-center retrospective study encompassed 511 CITNs selected from 509 patients between January 2020 and July 2023.Each nodule underwent surgical treatment and was classified according to three distinct systems. Receiver operating characteristic (ROC) curves were plotted using histopathological diagnosis as the reference standard, and diagnostic performance was compared.

resultsThe three ultrasound stratification systems showed an elevated malignant risk with increasing grades (all P for trend

conclusionKorean, American and Chinese stratification systems present potential in the differential diagnosis of CITNs. BRAF (V600E) mutation can significantly improve the detection rate of malignant nodules within CTNs, particularly PTC. Notably, the American and Chinese systems demonstrate superior overall diagnostic performance among these systems.

Indexed as

MutationProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid NeoplasmsThyroid NoduleUltrasonographyAdultAgedChinaEast Asian PeopleFemaleHumansMaleMiddle AgedNorth American PeopleRepublic of KoreaBRAF protein, humanProto-Oncogene Proteins B-rafBRAF (V600E)CytologyFine needle aspirationThyroid nodulesUltrasound

Identifiers

PMID37940765
OpenAlexW4388509754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.