Evidence map›Paper›PMID 37940687›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2024

Astrocytic transcriptional and epigenetic mechanisms of drug addiction.

Leanne M Holt, Eric J Nestler

Open access · greenAbstract readReview
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

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  13. "Unraveling the role ofReceptors (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leanne M HoltNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. leanne.holt@mssm.edu.ORCID 0000-0003-0954-2298
Eric J NestlerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eric.nestler@mssm.edu.
Allen Institute for Brain Science · US

Funding

Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YASMIN L. HURD · 2019 to 2026
$16.5M
Glial-mediated synaptic remodeling in drug addictionR01DA040620 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong, ERIC J. NESTLER · 2016 to 2026
$5.3M
Cocaine-induced adaptation in NMDA receptorsR37DA023206 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2018 to 2026
$3.9M
Training Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6M
NIDA NIH HHS P01 DA047233NIDA NIH HHS R01 DA040620NIDA NIH HHS R37 DA023206NIDA NIH HHS T32 DA053558NIDA NIH HHS T32DA053558NIH HHS P01DA047233
6 · The paper itself

Abstract

Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are thought to underlie behavioral adaptations. Emerging evidence implicates astrocytes in regulating drug-seeking behaviors and demonstrates robust transcriptional response to several substances of abuse. This review focuses on the astrocytic transcriptional and epigenetic mechanisms of drug action.

Indexed as

AstrocytesEpigenesis, GeneticSubstance-Related DisordersAnimalsHumansTranscription, Geneticalcoholcannabinoidscocaineglianicotineopioids

Identifiers

PMID37940687
PMCPMC11066772
OpenAlexW4388486711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.