Evidence map›Paper›PMID 37940594›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Current Status and Future Strategies for Advancing Functional Circuit Mapping

Andre Berndt, Denise Cai, Adam Cohen, Barbara Juarez, Jaume Taura Iglesias, Hejian Xiong, Zhenpeng Qin, Lin Tian, Paul A Slesinger

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Andre BerndtUniversity of Washington, Seattle, WA 98109 berndtuw@uw.edu.ORCID 0000-0003-4758-5598
Denise CaiIcahn School of Medicine at Mount Sinai, New York, NY 10029.
Adam CohenHarvard University, Cambridge, MA 02138.ORCID 0000-0002-8699-2404
Barbara JuarezUniversity of Maryland-Baltimore, Baltimore, MD 21201.ORCID 0000-0001-7897-8031
Jaume Taura IglesiasIcahn School of Medicine at Mount Sinai, New York, NY 10029.
Hejian XiongSouthern Medical University, Guangzhou, China.
Zhenpeng QinUniversity of Texas-Dallas, Richardson, TX 75080.ORCID 0000-0003-3406-3045
Lin TianUniversity of California-Davis, Davis, CA 95616.
Paul A SlesingerIcahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-3868-7528
Icahn School of Medicine at Mount Sinai · USHarvard University · USSouthern Medical University · CNThe University of Texas at Dallas · USUniversity of California, Davis · USUniversity of Maryland, Baltimore · USUniversity of Washington · US

Funding

Structural Analysis of Alcohol-dependent Activation of GIRKsR01AA018734 · NIAAA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Paul A Slesinger · 2010 to 2026
$6.6M
High-throughput engineering of ligand-selective fluorescent biosensors for detecting endogenous and exogenous opioidsRF1MH130391 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNDT, ANDRE, BRUCHAS, MICHAEL R. · 2023 to 2023
$2.5M
Development of new photo-releasable neuropeptide nano-vesicles for studying modulation in the brainRF1NS110499 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI QIN, ZHENPENG, SLESINGER, PAUL A · 2019 to 2019
$2.4M
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen speciesR01GM139850 · NIGMS · UNIVERSITY OF WASHINGTON · PI BERNDT, ANDRE · 2021 to 2024
$1.6M
Dopamine Circuit Regulation of Morphine Reinforcement Across the Opioid Exposure CycleR00DA054265 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI JUAREZ, BARBARA · 2023 to 2025
$823k
Protein ticker-tapes for brain-wide neural recordingsR21EY033669 · NEI · HARVARD UNIVERSITY · PI COHEN, ADAM EZRA · 2022 to 2023
$676k
Dopamine circuit regulation of morphine reinforcement across the opioid exposure cycleK99DA054265 · NIDA · UNIVERSITY OF WASHINGTON · PI JUAREZ, BARBARA · 2021 to 2022
$344k
NEI NIH HHS R21 EY033669NIAAA NIH HHS R01 AA018734NIDA NIH HHS K99 DA054265NIDA NIH HHS R00 DA054265NIGMS NIH HHS R01 GM139850NIMH NIH HHS RF1 MH130391NINDS NIH HHS RF1 NS110499
6 · The paper itself

Abstract

The human brain represents one of the most complex biological systems, containing billions of neurons interconnected through trillions of synapses. Inherent to the brain is a biochemical complexity involving ions, signaling molecules, and peptides that regulate neuronal activity and allow for short- and long-term adaptations. Large-scale and noninvasive imaging techniques, such as fMRI and EEG, have highlighted brain regions involved in specific functions and visualized connections between different brain areas. A major shortcoming, however, is the need for more information on specific cell types and neurotransmitters involved, as well as poor spatial and temporal resolution. Recent technologies have been advanced for neuronal circuit mapping and implemented in behaving model organisms to address this. Here, we highlight strategies for targeting specific neuronal subtypes, identifying, and releasing signaling molecules, controlling gene expression, and monitoring neuronal circuits in real-time

Indexed as

BrainNeuronsBrain MappingHumansMagnetic Resonance ImagingSynapses

Identifiers

PMID37940594
PMCPMC10634581
OpenAlexW4388486708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.