Evidence map›Paper›PMID 37940590›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Listening to the Data: Computational Approaches to Addiction and Learning.

Courtney S Wilkinson, Miguel Á Luján, Claire Hales, Kauê M Costa, Vincenzo G Fiore, Lori A Knackstedt, Hedy Kober

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Model-based analysis of stop-signal data reveals robust neural and clinical correlates of evidence accumulation but not inhibition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Courtney S WilkinsonDepartment of Psychology, University of Florida, Gainesville, Florida 32611 c.wilkinson@ufl.edu.ORCID 0000-0003-1834-7021
Miguel Á LujánDepartment of Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201.
Claire HalesDepartment of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Kauê M CostaNational Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland 21224.ORCID 0000-0002-5562-6495
Vincenzo G FioreDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, New York 10029.ORCID 0000-0002-4865-5482
Lori A KnackstedtDepartment of Psychology, University of Florida, Gainesville, Florida 32611.
Hedy KoberDepartments of Psychiatry, Psychology, and Neuroscience, Yale University, New Haven, Connecticut 06511.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Regulation of Craving: Clinical Trial and Neural MechanismsR01AA029137 · NIAAA · YALE UNIVERSITY · PI KOBER, HEDY · 2021 to 2025
$3.4M
Identifying patterns of human polysubstance use to guidedevelopment of rodent modelsR33DA045140 · NIDA · UNIVERSITY OF FLORIDA · PI COTTLER, LINDA B., KNACKSTEDT, LORI A · 2020 to 2022
$1.7M
Meta-Analysis and Machine Learning: Towards Neuromarkers of Craving and RelapseR01DA043690 · NIDA · YALE UNIVERSITY · PI KOBER, HEDY · 2017 to 2019
$1.3M
Patterns and neurocognitive consequences of opioid-alcohol polysubstance useR61DA056922 · NIDA · UNIVERSITY OF FLORIDA · PI COTTLER, LINDA B., KNACKSTEDT, LORI A · 2023 to 2024
$882k
Patterns and neurocognitive consequences of opioid-alcohol polysubstance useR33DA056922 · NIDA · UNIVERSITY OF FLORIDA · PI COTTLER, LINDA B., KNACKSTEDT, LORI A · 2025 to 2025
$736k
Identifying patterns of human polysubstance use to guidedevelopment of rodent modelsR21DA045140 · NIDA · UNIVERSITY OF FLORIDA · PI COTTLER, LINDA B., KNACKSTEDT, LORI A · 2018 to 2019
$424k
Oxytocin regulation of intravenous oxycodone demand: a role for nucleus accumbensF31DA057806 · NIDA · UNIVERSITY OF FLORIDA · PI WILKINSON, COURTNEY · 2023 to 2024
$73k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA029137NIDA NIH HHS F31 DA057806NIDA NIH HHS R01 DA043690NIDA NIH HHS R21 DA045140NIDA NIH HHS R33 DA045140NIDA NIH HHS R33 DA056922NIDA NIH HHS R61 DA056922
6 · The paper itself

Abstract

Computational approaches hold great promise for identifying novel treatment targets and creating translational therapeutics for substance use disorders. From circuitries underlying decision-making to computationally derived neural markers of drug-cue reactivity, this review is a summary of the approaches to data presented at our 2023 Society for Neuroscience Mini-Symposium. Here, we highlight data- and hypothesis-driven computational approaches that recently afforded advancements in addiction and learning neuroscience. First, we discuss the value of hypothesis-driven algorithmic modeling approaches, which integrate behavioral, neural, and cognitive outputs to refine hypothesis testing. Then, we review the advantages of data-driven dimensionality reduction and machine learning methods for uncovering novel predictor variables and elucidating relationships in high-dimensional data. Overall, this review highlights recent breakthroughs in cognitive mapping, model-based analysis of behavior/risky decision-making, patterns of drug taking, relapse, and neuromarker discovery, and showcases the benefits of novel modeling techniques, across both preclinical and clinical data.

Indexed as

Behavior, AddictiveSubstance-Related DisordersHumansMachine LearningRisk-Taking

Identifiers

PMID37940590
PMCPMC10634572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.