Evidence map›Paper›PMID 37940231›Full record

ArticleJournal of the American College of Cardiology2023

Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes.

Emily S Lau, Paolo Di Achille, Kavya Kopparapu, Carl T Andrews, Pulkit Singh, Christopher Reeder, Mostafa Al-Alusi, Shaan Khurshid, Julian S Haimovich, Patrick T Ellinor and 4 more

Abstract read
In one paragraph

Article in Journal of the American College of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Emily S LauDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Paolo Di AchilleData Sciences Platform, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Kavya KopparapuData Sciences Platform, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Carl T AndrewsDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pulkit SinghData Sciences Platform, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Christopher ReederData Sciences Platform, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Mostafa Al-AlusiDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Shaan KhurshidDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Julian S HaimovichDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Patrick T EllinorDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Michael H PicardDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Puneet BatraCardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Data Sciences Platform, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Steven A LubitzDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jennifer E HoCardiovascular Disease Initiative, Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; CardioVascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Electronic address: jho@bidmc.harvard.edu.

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Eicosanoid Profiles as Determinants of HFpEFR01HL140224 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2018 to 2021
$3.1M
Using Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9M
The Association of Metabolic Disease and Pulmonary HypertensionR01HL134893 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2017 to 2021
$2.9M
Long-Term Endothelial Effects of COVID-19 in ObesityR01HL160003 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAMBURG, NAOMI MIRIAM, HO, JENNIFER E · 2022 to 2025
$2.8M
Mentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2M
HFpEF Susceptibility in Women: The Role of InflammationK23HL159243 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Emily Lau · 2022 to 2026
$1.1M
Electrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimationK23HL169839 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shaan Khurshid · 2023 to 2026
$860k
Mentoring in Patient-Oriented and Translational HFpEF ResearchK24HL153669 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jennifer E Ho · 2020 to 2026
$744k
American Heart Association-American Stroke Association 18SFRN34250007NHLBI NIH HHS K23 HL159243NHLBI NIH HHS K23 HL169839NHLBI NIH HHS K24 HL105780NHLBI NIH HHS K24 HL153669NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL134893NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL140224NHLBI NIH HHS R01 HL157635NHLBI NIH HHS R01 HL160003NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

backgroundDeep learning interpretation of echocardiographic images may facilitate automated assessment of cardiac structure and function.

objectivesWe developed a deep learning model to interpret echocardiograms and examined the association of deep learning-derived echocardiographic measures with incident outcomes.

methodsWe trained and validated a 3-dimensional convolutional neural network model for echocardiographic view classification and quantification of left atrial dimension, left ventricular wall thickness, chamber diameter, and ejection fraction. The training sample comprised 64,028 echocardiograms (n = 27,135) from a retrospective multi-institutional ambulatory cardiology electronic health record sample. Validation was performed in a separate longitudinal primary care sample and an external health care system data set. Cox models evaluated the association of model-derived left heart measures with incident outcomes.

resultsDeep learning discriminated echocardiographic views (area under the receiver operating curve >0.97 for parasternal long axis, apical 4-chamber, and apical 2-chamber views vs human expert annotation) and quantified standard left heart measures (R

conclusionsDeep learning echocardiographic interpretation accurately quantified standard measures of left heart structure and function, which in turn were associated with future clinical outcomes. Deep learning may enable automated echocardiogram interpretation and disease prediction at scale.

Indexed as

Atrial FibrillationDeep LearningHeart FailureHumansRetrospective StudiesStroke VolumeVentricular Function, Leftcardiovascular diseasedeep learningechocardiographyelectronic health record

Identifiers

PMID37940231
PMCPMC10696641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.