Evidence map›Paper›PMID 37940188›Full record

ArticleLife science alliance2024

DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection.

Neysha Tirado-Class, Caitlin Hathaway, Anthony Nelligan, Thuan Nguyen, Huzefa Dungrawala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Neysha Tirado-ClassDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA.
Caitlin HathawayDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA.
Anthony NelliganDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA.
Thuan NguyenDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA.
Huzefa DungrawalaDepartment of Molecular Biosciences, University of South Florida, Tampa, FL, USA hdungrawala@usf.edu.ORCID 0000-0003-1868-7923
University of South Florida · US

Funding

Molecular Mechanisms of Replication Stress ResponseR35GM137800 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI Huzefa Mannan Dungrawala · 2020 to 2026
$2.3M
NIGMS NIH HHS R35 GM137800
6 · The paper itself

Abstract

DDB1- and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are substrate receptors for Cullin4-RING E3 ubiquitin ligase (CRL4) complexes. CDT2 is responsible for PCNA-coupled proteolysis of substrates CDT1, p21, and SET8 during S-phase of cell cycle. DCAF14 functions at stalled replication forks to promote genome stability, but the mechanism is unknown. We find that DCAF14 mediates replication fork protection by regulating CRL4

Indexed as

DNA ReplicationNuclear ProteinsCell Cycle ProteinsS PhaseUbiquitin-Protein LigasesCell Cycle ProteinsNuclear ProteinsUbiquitin-Protein Ligases

Identifiers

PMID37940188
PMCPMC10631547
OpenAlexW4388501454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.