ArticleBMJ open2023
Evaluating the performance of artificial intelligence software for lung nodule detection on chest radiographs in a retrospective real-world UK population.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pooled it
- Article
- Reply to Ismayilli et al. Comment on "Megat Ramli et al. A Systematic Review: The Role of Artificial Intelligence in Lung Cancer Screening in Detecting Lung Nodules on Chest X-Rays.Diagnostics (Basel, Switzerland) · 2026Article
- Assessing GPT-4 multimodal performance in radiological image analysis.European radiology · 2025Article
- A Thorough Review of the Clinical Applications of Artificial Intelligence in Lung Cancer.Cancers · 2025Review
- A Systematic Review: The Role of Artificial Intelligence in Lung Cancer Screening in Detecting Lung Nodules on Chest X-Rays.Diagnostics (Basel, Switzerland) · 2025Review
- Evolving and Novel Applications of Artificial Intelligence in Thoracic Imaging.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Artificial intelligence in modern clinical practice (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
objectivesEarly identification of lung cancer on chest radiographs improves patient outcomes. Artificial intelligence (AI) tools may increase diagnostic accuracy and streamline this pathway. This study evaluated the performance of commercially available AI-based software trained to identify cancerous lung nodules on chest radiographs.
designThis retrospective study included primary care chest radiographs acquired in a UK centre. The software evaluated each radiograph independently and outputs were compared with two reference standards: (1) the radiologist report and (2) the diagnosis of cancer by multidisciplinary team decision. Failure analysis was performed by interrogating the software marker locations on radiographs.
participants5722 consecutive chest radiographs were included from 5592 patients (median age 59 years, 53.8% women, 1.6% prevalence of cancer).
resultsCompared with radiologist reports for nodule detection, the software demonstrated sensitivity 54.5% (95% CI 44.2% to 64.4%), specificity 83.2% (82.2% to 84.1%), positive predictive value (PPV) 5.5% (4.6% to 6.6%) and negative predictive value (NPV) 99.0% (98.8% to 99.2%). Compared with cancer diagnosis, the software demonstrated sensitivity 60.9% (50.1% to 70.9%), specificity 83.3% (82.3% to 84.2%), PPV 5.6% (4.8% to 6.6%) and NPV 99.2% (99.0% to 99.4%). Normal or variant anatomy was misidentified as an abnormality in 69.9% of the 943 false positive cases.
conclusionsThe software demonstrated considerable underperformance in this real-world patient cohort. Failure analysis suggested a lack of generalisability in the training and testing datasets as a potential factor. The low PPV carries the risk of over-investigation and limits the translation of the software to clinical practice. Our findings highlight the importance of training and testing software in representative datasets, with broader implications for the implementation of AI tools in imaging.
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