Evidence map›Paper›PMID 37939495›Full record

ArticleResearch in developmental disabilities2023

Cognition, academic achievement, and adaptive behavior in school-aged girls with fragile X syndrome.

Tracy L Jordan, Kristi L Bartholomay, Cindy Hsin-Yu Lee, Amy A Lightbody, Allan L Reiss

Open access · greenAbstract read
In one paragraph

Article in Research in developmental disabilities, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tracy L JordanCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
Kristi L BartholomayCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
Cindy Hsin-Yu LeeCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
Amy A LightbodyCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA; Department of Radiology, Stanford University School of Medicine, USA; Department of Pediatrics, Stanford University School of Medicine, USA. Electronic address: areiss1@stanford.edu.
Stanford University · US

Funding

NEUROPSYCHIATRIC-MOLECULAR ASSOCIATIONS IN FRAGILE X SYNR01MH050047 · NIMH · STANFORD UNIVERSITY · PI REISS, ALLAN L · 1993 to 2022
$12.5M
TRAINING FOR CHILD PSYCHIATRY AND CHILD DEVELOPMENTT32MH019908 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB, DAVID S HONG · 1993 to 2026
$6.3M
NIMH NIH HHS R01 MH050047NIMH NIH HHS T32 MH019908
6 · The paper itself

Abstract

backgroundFragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and autism in males and females. Females with FXS typically display a milder cognitive phenotype than males, despite experiencing significant developmental, behavioral, and social-emotional issues.

aimsTo measure and distinguish the cognitive-behavioral profile of girls with FXS relative to verbal IQ-matched peers. METHODS AND PROCEDURES: Ninety-seven participants (N OUTCOMES AND

resultsConsistent with previous studies, the FXS group demonstrated mean cognitive skills, academic achievement, and adaptive behavior in the borderline to low average range. On average, the FXS group showed poorer nonverbal reasoning, visual pattern recognition, verbal abstraction, math abilities, attention, inhibitory control, and working memory than the comparison group. There were no significant group differences in adaptive behavior. Different patterns of associations between cognition and selected outcomes emerged in each group. CONCLUSIONS AND IMPLICATIONS: Results highlight the importance of identifying specific cognitive-behavioral profiles in girls with FXS to inform more targeted interventions for optimizing outcomes and quality of life in this population.

Indexed as

Academic SuccessFragile X SyndromeAdaptation, PsychologicalChildCognitionFemaleHumansMaleQuality of LifeAcademicAdaptiveAdolescentsChildrenCognition

Identifiers

PMID37939495
PMCPMC10842844
OpenAlexW4388440275

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.