Evidence map›Paper›PMID 37939288›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration.

Da-Wang Zhao, Qian Cheng, Huimin Geng, Jinbo Liu, Yuanqiang Zhang, Jiwei Cui, Chao Liu, Lei Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Da-Wang ZhaoDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Qian ChengKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Huimin GengKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Jinbo LiuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Yuanqiang ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Jiwei CuiKey Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong, 250100, China.
Chao LiuDepartment of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Lei ChengDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.ORCID 0000-0003-0856-5359
Qilu Hospital of Shandong University · CNShandong University · CNShanghai Jiao Tong University · CN

Funding

Innovation Project of Jinan Science and Technology Bureau 2020GXRC022National key research and development program 2020YFC2009004National Natural Science Foundation of China 82272548Natural Science Foundation of Shandong Province of China ZR2022MH019：ZR2023MH194Project for Scientific Research Innovation Team of Young Scholar in Colleges and Universities of Shandong Province 2020KJC001Project funded by China Postdoctoral Science Foundation 2021M690106Shandong University Horizontal Project 6010120012
6 · The paper itself

Abstract

A major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism. The phenotype of macrophages in the local immune microenvironment greatly influences the balance of ECM metabolism. Therefore, the control over the macrophage phenotype of the ECM is promising to repair intervertebral disk degeneration. Herein, the preparation of an injectable nanocomposite hydrogel is reported by embedding epigallocatechin-3-gallate-coated hydroxyapatite nanorods in O-carboxymethyl chitosan cross-linked with aldehyde hyaluronic acid that is capable of modulating the phenotype of macrophages. The bioactive components play a primary role in repairing the nucleus pulposus, where the hydroxyapatite nanorods can promote anabolism in the ECM through the nucleopulpogenic differentiation of mesenchymal stem cells. In addition, epigallocatechin-3-gallate can decrease catabolism in the ECM in nucleus pulposus by inducing M2 macrophage polarization, which exists in normal intervertebral disks and can alleviate degeneration. The nanocomposite hydrogel system shows promise for the minimally invasive and effective treatment of intervertebral disk degeneration by controlling anabolism and catabolism in the ECM and inhibiting the IL17 signaling pathway (M1-related pathway) in vitro and in vivo.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationHumansHydrogelsHydroxyapatitesNanogelsHydrogelsHydroxyapatitesNanogelshydroxyapatite nanorodsintervertebral disk degenerationmacrophage polarizationpolymer hydrogelspolyphenol

Identifiers

PMID37939288
PMCPMC10767410
OpenAlexW4388485938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.