ArticleAngewandte Chemie (International ed. in English)2023
Nickel-Catalyzed Enantioselective Decarboxylative Acylation: Rapid, Modular Access to α-Amino Ketones.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ni-Catalyzed Electrochemical Carbonylative Ketone Synthesis Employing a Radical Sorting Strategy.Angewandte Chemie (International ed. in English) · 2026Article
- Direct Synthesis of α‑Amino Ketones via Photochemical Nickel-Catalyzed Acyl-Aryl Cross-Coupling.ACS omega · 2025Article
- Highly Enantioselective Decarboxylative Difluoromethylation.Journal of the American Chemical Society · 2024Article
- A decarbonylative approach to alkylnickel intermediates and C(spScience (New York, N.Y.) · 2024Article
- Versatile, Modular, and General Strategy for the Synthesis of α-Amino Carbonyls.Journal of the American Chemical Society · 2024Article
- Regio- and enantioselective nickel-alkyl catalyzed hydroalkylation of alkynes.Nature communications · 2024Article
- Total syntheses of (-)-macrocalyxoformins A and B and (-)-ludongnin C.Nature communications · 2024Article
- Enantioselective C(spAccounts of chemical research · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
A new approach to the enantiocontrolled synthesis of α-amino ketone derivatives is disclosed by employing a decarboxylative acylation strategy. Thus, when an acyl chloride and an α-amido-containing redox-active ester are exposed to a nickel catalyst, chiral ligand, and metal reductant, α-amido ketones are produced in good yield and high ee. The reaction exhibits broad substrate scope, can be easily scaled up, and is applied to dramatically simplify the synthesis of several known structures.
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