ArticleJournal of the American Chemical Society2023
In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121.
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Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
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- Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase.Nature communications · 2026Article
- Can ferric-oxyl excited states explain elongated iron-oxygen bonds in heme peroxidase catalytic intermediates?Nature communications · 2026Article
- Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption.Nature communications · 2025Review
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- XFEL crystallography reveals catalytic cycle dynamics during non-native substrate oxidation by cytochrome P450BM3.Communications chemistry · 2025Article
- Indole N-Linked Hydroperoxyl Adduct of Protein-Derived Cofactor Modulating Catalase-Peroxidase Functions.Angewandte Chemie (International ed. in English) · 2024Article
- Innovative Strategies in X-ray Crystallography for Exploring Structural Dynamics and Reaction Mechanisms in Metabolic Disorders.Journal of personalized medicine · 2024Review
- A snapshot love story: what serial crystallography has done and will do for us.Acta crystallographica. Section D, Structural biology · 2024Review
- Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography.Nature communications · 2024Article
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- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 2 countries.
Romie C NguyenDepartment of Chemistry, University of Texas, San Antonio, Texas 78249, United States.
Ian DavisDepartment of Chemistry, University of Texas, San Antonio, Texas 78249, United States.ORCID 0000-0002-1566-4972
Medhanjali DasguptaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Yifan WangDepartment of Chemistry, University of Texas, San Antonio, Texas 78249, United States.
Philipp S SimonMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-2859-4475
Agata ButrynDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-5227-4770
Hiroki MakitaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Isabel BogaczMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-1493-3867
Kednerlin DornevilDepartment of Chemistry, University of Texas, San Antonio, Texas 78249, United States.
Pierre AllerDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-1793-7030
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-6154-6635
Ruchira ChatterjeeMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
In-Sik KimMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Tiankun ZhouDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.
Derek MendezMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Daniel W PaleyMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Franklin FullerLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
Roberto Alonso MoriLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-5357-0934
Alexander BatyukLCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.ORCID 0000-0002-9393-2880
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0003-2786-6552
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-0908-7822
Allen M OrvilleDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.ORCID 0000-0002-7803-1777
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0002-3983-7858
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID 0000-0001-6308-9071
Jan F KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Aimin LiuDepartment of Chemistry, University of Texas, San Antonio, Texas 78249, United States.ORCID 0000-0002-4182-8176
Lawrence Berkeley National Laboratory · USThe University of Texas at San Antonio · USRutherford Appleton Laboratory · GBSLAC National Accelerator Laboratory · US
Funding
Taking Snapshots of the Water-Oxidation Reaction by the Mn4Ca Oxygen-Evolving Complex Using X-ray Crystallography and SpectroscopyR01GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 1997 to 2022
$9.1MStructural Dynamics at LCLSP41GM139687 · NIGMS · STANFORD UNIVERSITY · PI HUNTER, MARK · 2021 to 2025
$7.5MDIALS: New Computational Methods to Enable Challenging Crystallographic ExperimentsR01GM117126 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SAUTER, NICHOLAS K · 2016 to 2023
$6.1MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MHeme-dependent chemistry in tyrosine oxidation: Diversity Supplement on 5R01GM108988-08 for supporting Samuel MontoyaR01GM108988 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIU, AIMIN · 2014 to 2025
$4.2MTaking Snapshots of Enzymatic Reactions Using X-ray Crystallography and SpectroscopyR35GM149528 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VITTAL YACHANDRA · 2023 to 2026
$2.7MHigh-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7MStructure and Function of the Mn Oxygen-Evolving ComplexR56GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 2009 to 2009
$530kNIGMS NIH HHS P41 GM139687NIGMS NIH HHS R01 GM055302NIGMS NIH HHS R01 GM108988NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM117126NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R35 GM149528NIGMS NIH HHS R56 GM055302NIH HHS S10 OD023453Wellcome Trust
Abstract
The P450 enzyme CYP121 from
Indexed as
Peracetic AcidPeroxidesCarbonCytochrome P-450 Enzyme SystemHemeIronLigandsTyrosineCarboncytochrome P-450 CYP121Cytochrome P-450 Enzyme SystemHemeIronLigandsPeracetic AcidPeroxidesTyrosine
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