Evidence map›Paper›PMID 37938890›Full record

ArticleIET systems biology2023

Kinetic modelling of β-cell metabolism reveals control points in the insulin-regulating pyruvate cycling pathways.

Rahul Rahul, Adam R Stinchcombe, Jamie W Joseph, Brian Ingalls

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IET systems biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rahul RahulDepartment of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0002-0144-1022
Adam R StinchcombeDepartment of Mathematics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-9082-4286
Jamie W JosephSchool of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0002-6847-534X
Brian IngallsDepartment of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0003-2118-3881
University of Waterloo · CAUniversity of Toronto · CA

Funding

Canadian Natural Resources LimitedNatural Sciences and Engineering Research Council of Canada RGPIN-2016-04145Natural Sciences and Engineering Research Council of Canada RGPIN-2018-03826
6 · The paper itself

Abstract

Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β-cells in response to elevated glucose levels. Insulin is released in a biphasic manner in response to glucose metabolism in β-cells. The first phase of insulin secretion is triggered by an increase in the ATP:ADP ratio; the second phase occurs in response to both a rise in ATP:ADP and other key metabolic signals, including a rise in the NADPH:NADP

Indexed as

Diabetes Mellitus, Type 2InsulinAdenosine TriphosphateGlucoseHumansNADPPyruvic AcidAdenosine TriphosphateGlucoseInsulinNADPPyruvic Acidbeta-cell metabolismglobal sensitivity analysismathematical modeltype 2 diabetes

Identifiers

PMID37938890
PMCPMC10725709
OpenAlexW4388488828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.