Evidence map›Paper›PMID 37938784›Full record

ArticleNature2023

Single-molecule dynamics show a transient lipopolysaccharide transport bridge.

Lisa Törk, Caitlin B Moffatt, Thomas G Bernhardt, Ethan C Garner, Daniel Kahne

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026
    Review
  6. Article
  7. Article
  8. Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. O-antigen polysaccharides inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  14. Review
  15. Article
  16. Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lisa TörkDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5194-1420
Caitlin B MoffattDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Thomas G BernhardtDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3566-7756
Ethan C GarnerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. egarner@g.harvard.edu.ORCID 0000-0003-0141-3555
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. Kahne@chemistry.harvard.edu.ORCID 0000-0002-8296-1424
Harvard University · USHoward Hughes Medical Institute · US

Funding

Outer Membrane Biogenesis: New Antibiotic TargetsR01AI081059 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2009 to 2026
$9.5M
Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Studies on the Biological Mechanisms of AntibioticsR01AI149778 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2020 to 2026
$4.7M
NIAID NIH HHS R01 AI081059NIAID NIH HHS R01 AI083365NIAID NIH HHS R01 AI149778
6 · The paper itself

Abstract

Gram-negative bacteria are surrounded by two membranes. A special feature of the outer membrane is its asymmetry. It contains lipopolysaccharide (LPS) in the outer leaflet and phospholipids in the inner leaflet

Indexed as

Bacterial Outer MembraneCarrier ProteinsGram-Negative BacteriaLipopolysaccharidesMembrane ProteinsBacterial Outer Membrane ProteinsBiological TransportEscherichia coliEscherichia coli ProteinsBacterial Outer Membrane ProteinsCarrier ProteinsEscherichia coli ProteinsLipopolysaccharidesMembrane Proteins

Identifiers

PMID37938784
PMCPMC10842706
OpenAlexW4388488584

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.