ArticleNature2023
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76citing papers in PubMed
21.5field-weighted citation impact, top 1% of its field
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Who cites it
76 citing papers in PubMed, 89 citations in OpenAlex.
- New antifungal and less toxic zwitterionic derivatives of 26-membered polyene antibiotic - pimaricin containingJournal of enzyme inhibition and medicinal chemistry · 2026Article
- Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast.iScience · 2026Article
- Natural Product-Inspired Antifungal Drugs Introduced for Human Use from 1872 to August 2026.Antibiotics (Basel, Switzerland) · 2026Review
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- Unpacking amphotericin B toxicity: a critical review of amphotericin B aggregation and its link to toxicity and antifungal activity.Archives of toxicology · 2026Review
- Repurposing of Clomiphene Citrate and Its Antileishmanial and Antifungal Activities:Biomolecules · 2026Article
- Sulfur Vacancy-Rich MoSAdvanced healthcare materials · 2026Article
- Innovation in antifungal therapy.EMBO molecular medicine · 2026Review
- A Cationic Supramolecule With Potent Antifungal Activity, Single-Species Selectivity, and Strong Synergy With Echinocandins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Non-Interventional, Retrospective, Multicenter Study on the Renal Safety of Liposomal Amphotericin B in Critically Ill Patients with Invasive Pulmonary Aspergillosis.Journal of fungi (Basel, Switzerland) · 2026Article
- In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy AgainstJournal of fungi (Basel, Switzerland) · 2026Article
- Contribution of fungal diseases to the U.S. chronic disease burden.Clinical microbiology reviews · 2026Review
- Emerging evidence for a multitude of mechanisms and factors that determine amphotericin B resistance in pathogenic fungi.Cell surface (Amsterdam, Netherlands) · 2026Review
- Nectriatides with No Antifungal Activity Bind to Ergosterol and Potentiate the Antifungal Activity of Amphotericin B againstACS omega · 2026Article
- Article
- Safety and efficacy of echinocandin antifungal agents inAntimicrobial agents and chemotherapy · 2026Article
- Targeting the polyene chain represents an adjuvant strategy for optimizing polyene antifungals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused byAntimicrobial agents and chemotherapy · 2026Article
- The chromatin remodeling factor Arp9 modulates drug-resistance and plays a key role in aflatoxins biosynthesis under mammalian-physiological-temperature in Aspergillus flavus.PLoS pathogens · 2026Article
16 more citing papers are in PubMed but not listed here.
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Authors and funding
38 authors at 8 institutions in 2 countries.
Arun Maji *Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Corinne P Soutar *Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-2087-7622
Jiabao ZhangDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Agnieszka LewandowskaDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Brice E UnoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Su YanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yogesh ShelkeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ganesh MurhadeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Evgeny NimerovskyDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Collin G BorcikMolecule Maker Lab, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Andres S ArangoCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Justin D LangeDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jonnathan P Marin-ToledoDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yinghuan LyuCarl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Keith L BaileyDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Patrick J RoadyDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jordan T HollerDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Anuj KhandelwalDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Anna M SantaMariaDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-8735-0721
Hiram SanchezDepartment of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, WI, USA.
Praveen R JuvvadiDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-5112-7824
Gina JohnsSfunga Therapeutics, Champaign, IL, USA.
Michael J HagemanDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
Joanna KriseDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA.
Teclegiorgis GebremariamDivision of Infectious Diseases, The Lundquist Institute, Torrance, CA, USA.ORCID 0000-0002-2295-058X
Eman G YoussefDivision of Infectious Diseases, The Lundquist Institute, Torrance, CA, USA.
Ken BartizalSfunga Therapeutics, Champaign, IL, USA.ORCID 0000-0003-4357-4605
Kieren A MarrSfunga Therapeutics, Champaign, IL, USA.
William J SteinbachDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ashraf S IbrahimDivision of Infectious Diseases, The Lundquist Institute, Torrance, CA, USA.ORCID 0000-0003-3787-8530
Thomas F PattersonDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Nathan P WiederholdDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-2225-5122
David R AndesDepartment of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-7927-9950
Taras V PogorelovBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-5851-7721
Charles D SchwietersComputational Biomolecular Magnetic Resonance Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4216-4658
Timothy M FanDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0003-2510-7050
Chad M RienstraDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. crienstra@wisc.edu.ORCID 0000-0002-9912-5596
Martin D BurkeBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. mdburke@illinois.edu.ORCID 0000-0001-7963-7140
University of Illinois Urbana-Champaign · USUniversity of Wisconsin–Madison · USThe University of Texas Health Science Center at San Antonio · USUniversity of Kansas · USArkansas Children's Hospital · USNational Institutes of Health · USUniversity of Arkansas for Medical Sciences · USUniversity of California, Los Angeles · US
Funding
Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3MMolecular Prosthetics and Lego ChemistryR35GM118185 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Martin D Burke · 2016 to 2026
$6.6MTechnologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4MToolkit for High-Resolution Structure and Dynamics of Functional LipidsR01GM123455 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MORRISSEY, JAMES H., RIENSTRA, CHAD M · 2016 to 2020
$5.0MDevelopment of non-toxic amphotericin B derivatives targeting invasive fungal infectionsR01AI135812 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANDES, DAVID R, BURKE, MARTIN D · 2018 to 2022
$3.7MStructures of Amphotericin-Sterol ComplexesR01GM112845 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RIENSTRA, CHAD M · 2015 to 2018
$1.8MStructural Biology and Biophysics of Alpha-Synuclein Fibrils by Solid-State NMRF32GM149118 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BORCIK, COLLIN GRIFFIN · 2023 to 2024
$143kNIAID NIH HHS R01 AI063503NIAID NIH HHS R01 AI135812NIGMS NIH HHS F32 GM149118NIGMS NIH HHS P41 GM136463NIGMS NIH HHS R01 GM112845NIGMS NIH HHS R01 GM123455NIGMS NIH HHS R35 GM118185
Abstract
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model
Indexed as
Antifungal AgentsKidneyPolyenesSterolsAmphotericin BAnimalsCells, CulturedCholesterolDrug Resistance, FungalErgosterolHumansKineticsMiceMicrobial Sensitivity TestsMycosesSerial PassageAmphotericin BAntifungal AgentsCholesterolErgosterolPolyenesSterols
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.