Evidence map›Paper›PMID 37938781›Full record

ArticleNature2023

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

Tom Le Voyer, Audrey V Parent, Xian Liu, Axel Cederholm, Adrian Gervais, Jérémie Rosain, Tina Nguyen, Malena Perez Lorenzo, Elze Rackaityte, Darawan Rinchai and 131 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Inherited human TFIIIA deficiency disrupts T cell development.medRxiv : the preprint server for health sciences · 2026
    Article
  7. Article
  8. How loss-of-function mutations inJournal of translational autoimmunity · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Review
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

141 authors at 20 institutions in 39 countries.

Tom Le VoyerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. tom.le-voyer@institutimagine.org.ORCID 0000-0002-7253-3135
Audrey V Parent *Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4506-6268
Xian Liu *Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Axel Cederholm *Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0009-0006-5973-9637
Adrian GervaisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Jérémie RosainLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Tina NguyenGarvan Institute of Medical Research, Sydney, New South Wales, Australia.
Malena Perez LorenzoLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0002-7933-5211
Elze RackaityteDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3889-8082
Darawan RinchaiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Peng ZhangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-6129-567X
Lucy BizienLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Gonca HanciogluDivision of Pediatric Allergy and Immunology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.ORCID 0000-0003-4221-6232
Pascale Ghillani-DalbinDepartment of Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Jean-Luc CharuelDepartment of Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Quentin PhilippotLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Mame Sokhna GueyeLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0002-5533-7757
Majistor Raj Luxman Maglorius RenkilarajLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Masato OgishiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Camille SoudéeLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Mélanie MigaudLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0003-3062-1214
Flore RozenbergVirology, Cochin-Saint-Vincent de Paul Hospital, University of Paris, Paris, France.
Mana MomenilandiLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Quentin RillerLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Paris Cité University, Imagine Institute, INSERM UMR1163, Paris, France.ORCID 0000-0003-3323-0235
Luisa ImbertiSection of Microbiology, University of Brescia, Brescia, Italy.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gabriele MüllerInstitute for Immunodeficiency, Center for Chronic Immunodeficiencies, Medical Center-University Hospital Freiburg, and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Baerbel KellerDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Julio OrregoPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
William Alexander Franco GallegoPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.
Tamar RubinDivision of Pediatric Clinical Immunology and Allergy, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Melike EmirogluDepartment of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey.ORCID 0000-0003-1307-0246
Nima ParvanehDivision of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3397-9716
Daniel ErikssonDepartment of Clinical Genetics, Uppsala University Hospital, Uppsala, Sweden.
Maribel Aranda-GuillenCenter for Molecular Medicine, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.ORCID 0000-0003-0050-704X
David I BerriosDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Linda VongDivision of Immunology and Allergy, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Constance H KatelarisImmunology and Allergy, University of Western Sydney and Campbelltown Hospital, Campbelltown, New South Wales, Australia.ORCID 0000-0002-4412-1336
Peter MustilloDivision of Allergy and Immunology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Johannes RaedlerDivision of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0003-0979-7274
Jonathan BohlenLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0003-0458-9484
Jale Bengi CelikDepartment of Anesthesiology and Reanimation, Selcuk University Faculty of Medicine, Konya, Turkey.
Camila AstudilloHospital de Niños Roberto del Río, Santiago, Chile.
Sarah WinterLaboratory of Lymphocyte Activation and Susceptibility to EBV, Paris Cité University, Imagine Institute, Inserm UMR1163, Paris, France.
NF-κB Consortium
COVID Human Genetic Effort
Catriona McLeanDepartment of Anatomical Pathology, The Alfred Hospital, Prahran, Victoria, Australia.
Aurélien GuffroyDepartment of Clinical Immunology and Internal Medicine, National Reference Center for Autoimmune Diseases, Strasbourg University Hospital, Strasbourg, France.
Joseph L DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
David YuDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Corey MillerDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1291-0074
Yi FengSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Audrey GuichardJoint Unit Hospices Civils de Lyon-BioMérieux, Lyon, France.
Vivien BéziatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0002-4020-824X
Jacinta BustamanteLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1990-8804
Yu ZhangLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Lindsey B RosenLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Steve M HollandLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3207-5464
Marita BosticardoLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Heather KenneyLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Riccardo CastagnoliPediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.ORCID 0000-0003-0029-9383
Charlotte A SladeImmunology Division, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia.
Kaan BoztuğCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Nizar MahlaouiFrench National Reference Center for Primary Immunodeficiencies (CEREDIH), Necker-Enfants University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Sylvain LatourLaboratory of Lymphocyte Activation and Susceptibility to EBV, Paris Cité University, Imagine Institute, Inserm UMR1163, Paris, France.
Roshini S AbrahamDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Vassilios LougarisDepartment of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia ASST-Spedali Civili di Brescia, Brescia, Italy.
Fabian HauckDivision of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID 0000-0001-9644-2003
Anna SedivaDepartment of Immunology, Second Faculty of Medicine Charles University and Motol University Hospital, Prague, Czech Republic.ORCID 0000-0001-7730-2304
Faranaz AtschekzeiDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Georgios SogkasDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
M Cecilia PoliHospital de Niños Roberto del Río, Santiago, Chile.ORCID 0000-0001-6817-0573
Mary A SlatterChildren's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle-upon-Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, UK.
Boaz PaltererAllergy and Clinical Immunology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Michael D KellerDivision of Allergy and Immunology, Children's National Medical Center, Washington, DC, USA.
Alberto Pinzon-CharryClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.
Anna SullivanClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.
Luke DroneyClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.ORCID 0000-0002-2126-8327
Daniel SuanClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.
Melanie WongClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.
Alisa KaneSchool of Clinical Medicine, UNSW Medicine & Health, Darlinghurst, New South Wales, Australia.
Hannah HuClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.
Cindy MaGarvan Institute of Medical Research, Sydney, New South Wales, Australia.ORCID 0000-0001-5387-8413
Hana GrombiříkováCentre for Cardiovascular Surgery and Transplantation, Medical Faculty, Masaryk University, Brno, Czech Republic.ORCID 0000-0002-9317-8531
Peter CiznarDepartment of Paediatrics, Faculty of Medicine, Comenius University Bratislava, Bratislava, Slovakia.ORCID 0000-0003-0566-1644
Ilan DalalPediatric Department, E. Wolfson Medical Center, Tel Aviv University, Tel Aviv, Israel.
Nathalie AladjidiPediatric Oncology Hematology Unit, University Hospital, Plurithématique CIC (CICP), Centre d'Investigation Clinique (CIC) 1401, Bordeaux, France.
Miguel HieInternal Medicine Department, Pitié-Salpêtrière Hospital, Paris, France.
Estibaliz LazaroDepartment of Internal Medicine & Infectious Diseases, Bordeaux Hospital University, Bordeaux, France.ORCID 0000-0002-4206-7399
Jose FrancoPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellín, Colombia.ORCID 0000-0001-5664-6415
Sevgi KelesDivision of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.ORCID 0000-0001-7344-8947
Marion MalphettesClinical Immunology Department, Saint Louis Hospital, Paris, France.
Marlene PasquetDepartment of Pediatric Hematology, Toulouse University Hospital, Toulouse, France.
Maria Elena MaccariInstitute for Immunodeficiency, Center for Chronic Immunodeficiencies, Medical Center-University Hospital Freiburg, and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Andrea MeinhardtDepartment of Pediatric Hematology, Oncology and Immunodeficiencies, University Children's Hospital Gießen, Giessen, Germany.ORCID 0000-0002-7464-0751
Aydan IkinciogullariDepartment of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.
Mohammad ShahrooeiDr. Shahrooei Lab, Tehran, Iran.
Fatih CelmeliDepartment of Allergy and Immunology, University of Medical Science, Antalya Education and Research Hospital, Antalya, Turkey.ORCID 0000-0002-2983-5058
Patrick FroskDepartment of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Christopher C GoodnowGarvan Institute of Medical Research, Sydney, New South Wales, Australia.ORCID 0000-0001-5296-6155
Paul E GrayClinical Immunogenomics Research Consortium Australasia (CIRCA), Darlinghurst, New South Wales, Australia.ORCID 0000-0003-2057-3968
Alexandre BelotCNRS UMR 5308, ENS, UCBL, Lyon, France.ORCID 0000-0003-4902-5332
Hye Sun KuehnImmunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Sergio D RosenzweigImmunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Makoto MiyaraDepartment of Immunology, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
Francesco LicciardiDepartment of Pediatrics and Public Health, Università degli Studi di Torino, Turin, Italy.
Amélie ServettazInternal Medicine, Clinical Immunology and Infectious Diseases Department, University Hospital Center, Reims, France.
Vincent BarlogisCHU Marseille, Hôpital La Timone, Service d'Hémato-oncologie Pédiatrique, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Guillaume Le GuennoCentre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.
Vera-Maria HerrmannInstitute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany.
Taco KuijpersDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Grégoire DucouxDepartment of Internal Medicine, Edouard Herriot Hospital, Lyon, France.
Françoise Sarrot-ReynauldDepartment of Internal Medicine, Hôpital Michallon, CHU de Grenoble Alpes, Grenoble, France.
Catharina SchuetzDepartment of Pediatrics, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Charlotte Cunningham-RundlesDepartments of Medicine and Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.ORCID 0000-0003-0725-0320
Frédéric Rieux-LaucatLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, Paris Cité University, Imagine Institute, INSERM UMR1163, Paris, France.ORCID 0000-0001-7858-7866
Stuart G TangyeGarvan Institute of Medical Research, Sydney, New South Wales, Australia.ORCID 0000-0002-5360-5180
Cristina SobacchiIRCCS Humanitas Research Hospital, Rozzano, Italy.
Rainer DoffingerDepartment of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.
Klaus WarnatzDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bodo GrimbacherInstitute for Immunodeficiency, Center for Chronic Immunodeficiencies, Medical Center-University Hospital Freiburg, and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Claire FieschiClinical Immunology Department, Saint Louis Hospital, Paris, France.
Laureline BertelootPediatric Radiology Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-9681-3142
Vanessa L BryantImmunology Division, Walter and Eliza Hall Institute, Melbourne, Victoria, Australia.
Sophie Trouillet AssantJoint Unit Hospices Civils de Lyon-BioMérieux, Lyon, France.
Helen SuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Benedicte NevenDepartment of Pediatric Immunology, Hematology and Rheumatology, Necker-Enfants Malades Hospital, AP-HP, Paris, France.
Laurent AbelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Qian ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Bertrand BoissonLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0001-5240-3555
Aurélie CobatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.ORCID 0000-0001-7209-6257
Emmanuelle JouanguyLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Olle KampeDepartment of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-6091-9914
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France.
Chaim M RoifmanDivision of Immunology and Allergy, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Nils LandegrenScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8335-0262
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3093-4758
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. casanova@rockefeller.edu.ORCID 0000-0002-7782-4169
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris, France. anne.puel@inserm.fr.ORCID 0000-0003-2603-0323
Inserm · FRNational Institutes of Health · USUniversity of California, San Francisco · USUniversity of Freiburg · DEHôpital Necker-Enfants Malades · FRUniversidade de São Paulo · BRUniversité Claude Bernard Lyon 1 · FRAgency for Science, Technology and Research · SGRockefeller University · USTel Aviv University · ILUniversidad de Antioquia · COVita-Salute San Raffaele University · ITCharles University · CZChildren's Health Queensland Hospital and Health Service · AUGarvan Institute of Medical Research · AUSorbonne Université · FRThe Royal Melbourne Hospital · AUUniversidad del Desarrollo · CLUniversity of Manitoba · CAAarhus University · DK

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7M
Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Anne Puel · 2017 to 2026
$4.8M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Thymic medullary epithelial cell turnover and control of immune toleranceR37AI097457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark S Anderson · 2017 to 2026
$4.0M
Inborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7M
Mechanisms of thymic stromal-immune crosstalk for homeostasis and naïve T cell licensing across lifeK01AG072789 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, COREY NICHOLAS · 2021 to 2025
$701k
Medical Research Council MR/S032304/1NCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI127564NIAID NIH HHS R01 AI163029NIAID NIH HHS R37 AI097457NIA NIH HHS K01 AG072789NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)

Indexed as

AutoantibodiesGenetic Predisposition to DiseaseInterferon Type INF-kappa BAIRE ProteinCOVID-19Gain of Function MutationHeterozygoteHumansI-kappa B ProteinsLoss of Function MutationNF-kappaB-Inducing KinaseNF-kappa B p52 SubunitPneumonia, ViralPolyendocrinopathies, AutoimmuneThymus GlandAIRE ProteinAutoantibodiesI-kappa B ProteinsInterferon Type INF-kappa BNF-kappaB-Inducing KinaseNF-kappa B p52 SubunitRELB protein, humanTranscription Factor RelB

Identifiers

PMID37938781
PMCPMC10665196
OpenAlexW4388488683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.