Evidence map›Paper›PMID 37938780›Full record

ArticleNature2023

Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis.

Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Ancient origins of alkaloid biosynthesis in medicinal clubmosses.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
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  16. Article
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ryan S NettDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA. rnett@fas.harvard.edu.ORCID 0000-0002-2537-7010
Yaereen DhoDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9557-8686
Chun TsaiHHMI, Stanford University, Stanford, CA, USA.
Daria PassowBiophysics Program, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0830-5330
Jaime Martinez GrundmanDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8294-1992
Yun-Yee LowDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
Elizabeth S SattelyDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA. sattely@stanford.edu.ORCID 0000-0002-7352-859X

Funding

Molecular Biophysics Training Program at StanfordT32GM136568 · NIGMS · STANFORD UNIVERSITY · PI Zev Bryant, KERWYN C. HUANG · 2021 to 2026
$3.7M
Discovery and Engineering of Plant Natural Product PathwaysR01GM121527 · NIGMS · STANFORD UNIVERSITY · PI SATTELY, ELIZABETH SUSAN · 2017 to 2025
$2.3M
Investigating neofunctionalized alpha-carbonic anhydrases as an emerging class of biosynthetic enzyme in plant and animal metabolismR35GM150908 · NIGMS · HARVARD UNIVERSITY · PI Ryan Stephan Nett · 2023 to 2026
$1.6M
NIGMS NIH HHS R01 GM121527NIGMS NIH HHS R35 GM150908NIGMS NIH HHS T32 GM136568
6 · The paper itself

Abstract

Plants synthesize numerous alkaloids that mimic animal neurotransmitters

Indexed as

AlkaloidsCarbonic AnhydrasesModels, NeurologicalPlantsAcetylcholinesteraseAnimalsCholinesterase InhibitorsGene Expression Regulation, PlantLycopodiumNeurotransmitter AgentsSesquiterpenesAcetylcholinesteraseAlkaloidsCarbonic AnhydrasesCholinesterase Inhibitorshuperzine ANeurotransmitter AgentsSesquiterpenes

Identifiers

PMID37938780
PMCPMC10700139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.