Evidence map›Paper›PMID 37938774›Full record

ArticleNature2023

Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements.

Zhiming Li, Shoufu Duan, Xu Hua, Xiaowei Xu, Yinglu Li, Demis Menolfi, Hui Zhou, Chao Lu, Shan Zha, Stephen P Goff and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

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  19. The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhiming Li *Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-5031-8362
Shoufu Duan *Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Xu HuaInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Xiaowei XuInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Yinglu LiDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.
Demis MenolfiInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-3824-9931
Hui ZhouInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Chao LuHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-0982-8122
Shan ZhaInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA.
Stephen P GoffHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-9679-0582
Zhiguo ZhangInstitute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY, USA. zz2401@cumc.columbia.edu.ORCID 0000-0002-9451-2685
Columbia University Irving Medical Center · USCancer Genetics (United States) · US

Funding

Mechanisms of Epigenetic inheritanceR35GM118015 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Zhiguo Zhang · 2016 to 2026
$9.5M
Regulation and Function of Histone H3K36 Methylation in Mammalian ChromatinR35GM138181 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LU, CHAO · 2020 to 2024
$2.0M
The structural function of ATR in development, oncogenesis and cancer therapyR01CA215067 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHA, SHAN · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA215067NIGMS NIH HHS R35 GM118015NIGMS NIH HHS R35 GM138181
6 · The paper itself

Abstract

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3 lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome instability and human diseases, including cancer and ageing

Indexed as

Gene SilencingHistonesLong Interspersed Nucleotide ElementsLysineS PhaseDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA Polymerase IIDNA Polymerase IIIDNA ReplicationHumansMethylationNuclear ProteinsNucleoproteinsPhosphoproteinsPoly-ADP-Ribose Binding ProteinsDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA Polymerase IIDNA Polymerase IIIHistonesLysineMPHOSPH8 protein, humanNuclear ProteinsNucleoproteinsPhosphoproteinsPOLE3 protein, humanPOLE4 protein, humanPOLE protein, humanPoly-ADP-Ribose Binding ProteinsTASOR protein, human

Identifiers

PMID37938774
PMCPMC11034792
OpenAlexW4388488624

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.