ArticleNature2023
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.
0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed
56.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
269 citing papers in PubMed, 340 citations in OpenAlex.
- Trial
- Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis.Nature communications · 2025Trial
- Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis.Clinical reviews in allergy & immunology · 2026Review
- Accurate and well-powered case-control analysis of spatial molecular data.Nature methods · 2026Article
- From psoriatic plaque to synovium: decoding the skin-joint axis in psoriatic arthritis.Nature reviews. Rheumatology · 2026Review
- An intelligent tribological hydrogel delivering 9,10-DiOH activates cuproptosis for comprehensive rheumatoid arthritis intervention.Materials today. Bio · 2026Article
- Multi-stromal organoid co-culture modelling reveals epithelial-fibroblast heterogeneity in pancreatic cancer and pancreatitis.Nature cell biology · 2026Article
- The regnase family in autoimmune diseases: a regnase-1-centered perspective on cellular heterogeneity.Molecular biology reports · 2026Review
- Immune-mediated rheumatoid arthritis: from single-cell genomics to new therapies.Nature immunology · 2026Review
- From Marginal to Central: Marginal Zone-like B Cells as Critical Targets in Cladribine-Treated Multiple Sclerosis.Annals of neurology · 2026Article
- Enrichment and Proteomic Profiling of Stromal-Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size-Exclusion Chromatography Coupled to CD90-Directed Immunocapture.Journal of extracellular vesicles · 2026Article
- Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis.European journal of immunology · 2026Article
- Hypoxia as an amplifier of synovial inflammation in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Multi-level transcriptional control of specific macrophage responses.The EMBO journal · 2026Review
- Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson's Disease Spectrum.medRxiv : the preprint server for health sciences · 2026Article
- Patient-Derived Transcriptomics Reveals Distinct IFNγ-Associated Myeloid States and Mitochondrial Complex I Programs in Rheumatoid Arthritis and Osteoarthritis.Biomedicines · 2026Article
- Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha-Amidating Monooxygenase Activity in Synovial Fibroblasts.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Identification and characterization of POSTNJournal of orthopaedic translation · 2026Article
- From Genome-Wide Association Study Signal to Mechanism in Rheumatoid Arthritis: Lessons From a Single Risk Locus.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Beyond B cell helpers: diverse roles of peripheral helper T cells.International immunology · 2026Review
209 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors at 20 institutions in 4 countries.
Fan Zhang *Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6102-2970
Anna Helena Jonsson *Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9558-2474
Aparna Nathan *Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nghia Millard *Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michelle CurtisDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6843-4839
Qian XiaoDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Maria Gutierrez-ArcelusDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7898-7691
William ApruzzeseAccelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Bethesda, MD, USA.
Gerald F M WattsDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dana WeisenfeldDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Saba NayarRheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Javier Rangel-MorenoDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-9738-1182
Nida MeednuDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Kathryne E MarksDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1524-7159
Ian MantelHospital for Special Surgery, New York, NY, USA.
Joyce B KangDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Laurie RumkerDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Joseph MearsDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kamil SlowikowskiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2843-6370
Kathryn WeinandDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dana E OrangeHospital for Special Surgery, New York, NY, USA.ORCID 0000-0001-9859-7199
Laura Geraldino-PardillaDivision of Rheumatology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Kevin D DeaneDivision of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-2211-4861
Darren TabechianDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Arnoldas CeponisDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
Gary S FiresteinDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3495-960X
Mark MayburyRheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0002-5031-1064
Ilfita SahbudinRheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0003-0702-4403
Ami Ben-ArtziDivision of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Arthur M MandelinDivision of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Alessandra NervianiCentre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-4064-4014
Myles J LewisCentre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0001-9365-5345
Felice RivelleseCentre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-6759-7521
Costantino PitzalisCentre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-1326-5051
Laura B HughesDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Diane HorowitzFeinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USA.
Edward DiCarloDepartment of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.
Ellen M GravalleseDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brendan F BoyceDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0002-3587-4854
Accelerating Medicines Partnership: RA/SLE Network
Larry W MorelandDivision of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.
Susan M GoodmanHospital for Special Surgery, New York, NY, USA.ORCID 0000-0003-1197-7864
Harris PerlmanDivision of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
V Michael HolersDivision of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.
Katherine P LiaoDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4797-3200
Andrew FilerRheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.ORCID 0000-0001-8164-6249
Vivian P BykerkHospital for Special Surgery, New York, NY, USA.
Kevin WeiDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1821-167X
Deepak A RaoDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9672-7746
Laura T DonlinHospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-1428-090X
Jennifer H AnolikDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Michael B BrennerDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6202-8445
Soumya RaychaudhuriDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID 0000-0002-1901-8265
Brigham and Women's Hospital · USBroad Institute · USHospital for Special Surgery · USUniversity of Rochester Medical Center · USQueen Elizabeth Hospital Birmingham · GBCedars-Sinai Medical Center · USNorthwestern University · USQueen Mary University of London · GBUniversity of Colorado Denver · USUniversity of Pittsburgh · USColumbia University · USOklahoma Medical Research Foundation · USStanford University · USUniversity of California San Diego · USHumanitas University · ITNational Institutes of Health · USNorthwell Health · USUniversity of Alabama at Birmingham · USUniversity of Birmingham · GBUniversity of Pittsburgh Medical Center · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MRole of fibroblastic stromal cells and notch signaling in tissue inflammation in RA and SLEP01AI148102 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nir Hacohen · 2021 to 2026
$17.3MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MMECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MPEARL: Pathway Exploration and Analysis in Renal LupusUH2AR067688 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, WOFSY, DAVID · 2014 to 2020
$9.0MTissue Acquisition Research GroupUM2AR067678 · NIAMS · STANFORD UNIVERSITY · PI HOLERS, VERNON MICHAEL, UTZ, PAUL JOSEPH · 2014 to 2020
$8.2MRochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8MResearch Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9MMulti-Ethnic Translational Research Optimization (METRO) Lupus ConsortiumUH2AR067689 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUYON, JILL P, PUTTERMAN, CHAIM · 2014 to 2020
$6.3MMedical Research Council MR/M007669/1Medical Research Council MR/P021220/1NCATS NIH HHS UL1 TR001866NHGRI NIH HHS T32 HG002295NHGRI NIH HHS U01 HG009379NIAID NIH HHS P01 AI148102NIAID NIH HHS R01 AI148435NIAID NIH HHS R01 AI175212NIAMS NIH HHS K08 AR072791NIAMS NIH HHS K08 AR077037NIAMS NIH HHS K08 AR081412NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P30 AR070253NIAMS NIH HHS R01 AR063759NIAMS NIH HHS R01 AR073290NIAMS NIH HHS R01 AR073833NIAMS NIH HHS R21 AR071670NIAMS NIH HHS T32 AR007258NIAMS NIH HHS T32 AR007530NIAMS NIH HHS UH2 AR067676NIAMS NIH HHS UH2 AR067677NIAMS NIH HHS UH2 AR067679NIAMS NIH HHS UH2 AR067681NIAMS NIH HHS UH2 AR067685NIAMS NIH HHS UH2 AR067688NIAMS NIH HHS UH2 AR067689NIAMS NIH HHS UH2 AR067690NIAMS NIH HHS UH2 AR067691NIAMS NIH HHS UH2 AR067694NIAMS NIH HHS UM2 AR067678NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
Abstract
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction
Indexed as
Arthritis, RheumatoidB-LymphocytesCytokinesGenetic Predisposition to DiseaseHumansInflammationPhenotypeSingle-Cell Gene Expression AnalysisSynovial MembraneT-LymphocytesCytokines
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