ArticleNature2023
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
23.8field-weighted citation impact, top 1% of its field
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Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.Nature cell biology · 2026Article
- Identification of methylation-sensitive human transcription factors using meSMiLE-seq.Nature communications · 2026Article
- Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Histochemistry and cell biology · 2026Article
- The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.Nature communications · 2026Article
- Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction.Cancer research · 2026Article
- LINE-1 retrotransposons: Multifaceted functions and regulatory mechanisms in health and disease.Molecular therapy. Nucleic acids · 2026Review
- Histone modifications across cancers: mechanisms, therapy and clinical translation.Molecular cancer · 2026Review
- Nuclear N-glycosylation maintains H3K9me3 heterochromatin and genomic stability.Nature cell biology · 2026Article
- BPabZIP, a new bZIP protein motif that promotes binding near, and displacement of, nucleosomes.bioRxiv : the preprint server for biology · 2026Article
- Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional programs of liver cells.Nature communications · 2026Article
- Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition.The Journal of biological chemistry · 2026Review
- Positive Selection Targeted Primate Genes that Encode Transposable Element Repressors.Genome biology and evolution · 2026Article
- Viral mimicry acts as a tumor suppressor in colitis.Nature communications · 2026Article
- Iparomlimab and tuvonralimab (QL1706) combined definitive chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma (QL1706-IIT-02): a single arm, phase 2 trial.EClinicalMedicine · 2026Article
- An RNA biomarker panel for the diagnosis of Alzheimer's disease from whole blood.Alzheimer's research & therapy · 2026Article
- Inducing tumor-intrinsic innate immune response to break cancer immunotherapy resistance.Frontiers in medicine · 2026Review
- Interferon dependent immune memory during HSV-1 neuronal latency via increased H3K9me3 and restriction by ATRX.Nature communications · 2025Article
- A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling.Nature communications · 2025Article
- Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcription by safeguarding Pol II occupancy in both germline and somatic tissues of Drosophila.Nucleic acids research · 2025Article
- SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.AMB Express · 2025Article
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 2 countries.
Shuai Zhao *Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Jiuwei Lu *Department of Biochemistry, University of California, Riverside, CA, USA.ORCID 0000-0002-6478-4081
Bo PanDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-2626-1589
Huitao FanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0001-8250-3696
Stephanie D ByrumDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0002-1783-3610
Chenxi XuDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Arum KimDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Yiran GuoDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Krishna L KanchiLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Weida GongLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-0046-9277
Tongyu SunDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Aaron J StoreyDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nathaniel T BurkholderDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-1769-3750
Samuel G MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Peyton C KuhlersDepartment of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Ricky D EdmondsonDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Brian D StrahlLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-4947-6259
Yarui DiaoDuke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-5842-4082
Alan J TackettDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jesse R RaabLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Ling CaiDuke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.
Jikui SongDepartment of Biochemistry, University of California, Riverside, CA, USA. jikui.song@ucr.edu.
Gang Greg WangDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. greg.wang@duke.edu.ORCID 0000-0002-7210-9940
University of North Carolina at Chapel Hill · USUniversity of Arkansas for Medical Sciences · USDuke University · USUniversity of California, Riverside · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MUser Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2MTranslational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett · 2017 to 2026
$27.6MSupplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4MMechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5MMechanistic Insights into Mammalian DNA MethylationR35GM119721 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Jikui Song · 2016 to 2026
$5.3MDiscovery of First-in-class WDR5 PROTACs as a Novel Therapeutic Strategy for MLL-rearranged LeukemiasR01CA268384 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jian Jin, G Greg Wang · 2022 to 2026
$3.9MDissecting and targeting canonical and non-canonical oncogenic functions of EZH2 in canerR01CA268519 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jian Jin, G Greg Wang · 2022 to 2026
$3.2MThe 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repairU01HL156064 · NHLBI · DUKE UNIVERSITY · PI DIAO, YARUI · 2020 to 2024
$3.0MThe role for phase separation in oncogenesis and aberrant chromatin looping formationR01CA271603 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Douglas H. Phanstiel, G Greg Wang · 2022 to 2026
$2.9MMulti-omics functional analysis of non-coding regulatory genome for genomic medicineR35HG011328 · NHGRI · DUKE UNIVERSITY · PI DIAO, YARUI · 2020 to 2024
$2.3MMechanisms of SWI/SNF complex assembly and functionR35GM147286 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jesse R. Raab · 2022 to 2026
$2.1MNCI NIH HHS P30 CA016086NCI NIH HHS R01 CA236209NCI NIH HHS R01 CA262903NCI NIH HHS R01 CA268384NCI NIH HHS R01 CA268519NCI NIH HHS R01 CA271603NHGRI NIH HHS R35 HG011328NHLBI NIH HHS U01 HL156064NIGMS NIH HHS P20 GM121293NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R24 GM137786NIGMS NIH HHS R35 GM119721NIGMS NIH HHS R35 GM126900NIGMS NIH HHS R35 GM147286
Abstract
Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene repression and heterochromatin formation, cell-fate determination and organismal development
Indexed as
Endogenous RetrovirusesGene SilencingHistonesIntracellular Signaling Peptides and ProteinsLysineRetroelementsAnimalsAnimals, NewbornCell LineChromatinCo-Repressor ProteinsEpigenesis, GeneticGene Expression ProfilingGenomeHistone DeacetylasesHumansChromatinCo-Repressor ProteinsHistone DeacetylasesHistonesIntracellular Signaling Peptides and ProteinsLysineRetroelementsTNRC18 protein, humanTnrc18 protein, mouse
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