ArticleNature2023
Latent human herpesvirus 6 is reactivated in CAR T cells.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
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Who cites it
40 citing papers in PubMed, 45 citations in OpenAlex.
- Identification of Two Competition-Defined Neutralizing Antibody Groups Targeting the HHV-6B gH/gL/gQ1/gQ2 Complex Independent of CD134 Binding.Microbiology and immunology · 2026Article
- The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects.Signal transduction and targeted therapy · 2026Review
- Resolving human neuronal herpesvirus reactivation via petabase-scale association studies.bioRxiv : the preprint server for biology · 2026Article
- A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.Nature communications · 2026Article
- Article
- Neurotoxicity of Immunotherapy: Immune Checkpoint Inhibitor-Related Encephalitis vs. Immune Effector Cell-Associated Neurotoxicity Syndrome.World journal of oncology · 2026Review
- Neurological implications of chimeric antigen receptor-T cell therapy.BMJ neurology open · 2026Review
- Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy.Nature communications · 2025Article
- Latent EBV reactivation drives aberrant B-cell proliferation during ex vivo tumor-infiltrating lymphocyte expansion from EBV-negative rectal cancer tumor tissue.Scientific reports · 2025Article
- Report of the fourth conference on next-generation sequencing (NGS) for adventitious virus detection in biologics for humans and animals: Validation and implementation of NGS.Biologicals : journal of the International Association of Biological Standardization · 2025Article
- 'Google for DNA' brings order to biology's big data.Nature · 2025Article
- Logan: Planetary-Scale Genome Assembly Surveys Life's Diversity.bioRxiv : the preprint server for biology · 2025Article
- Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening.Nature communications · 2025Article
- Population-scale sequencing resolves correlates and determinants of latent Epstein-Barr Virus infection.bioRxiv : the preprint server for biology · 2025Article
- Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition.PLoS pathogens · 2025Article
- From Multi-Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR-T Cell Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Human herpesvirus 6 (HHV-6) encephalitis secondary to chimeric antigen receptor (CAR)-T cell therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Reactivation of a Transplant Recipient's Inherited Human Herpesvirus 6 and Implications to the Graft.The Journal of infectious diseases · 2025Article
- The design of retroviral vectors used in the CAR-T products, risk management, and future perspective.MedComm · 2025Article
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Authors and funding
40 authors at 9 institutions in 3 countries.
Caleb A LareauDepartment of Pathology, Stanford University, Stanford, CA, USA. lareauc@mskcc.org.ORCID 0000-0003-4179-4807
Yajie YinDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2220-005X
Katie MaurerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-4160-181X
Katalin D SandorDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2892-4865
Bence DanielDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2410-8767
Garima YagnikAllogene Therapeutics, South San Francisco, CA, USA.
José PeñaAllogene Therapeutics, South San Francisco, CA, USA.ORCID 0000-0002-9662-906X
Jeremy Chase CrawfordDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4096-6048
Anne M SpanjaartDepartment of Hematology, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-0167-6021
Jacob C GutierrezDepartment of Pathology, Stanford University, Stanford, CA, USA.
Nicholas J HaradhvalaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1113-3135
Janice M RiberdyDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.
Tsion AbayDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0009-0009-0024-2732
Robert R StickelsDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4326-4084
Jeffrey M VerboonDepartment of Pathology, Stanford University, Stanford, CA, USA.
Vincent LiuDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6790-6603
Frank A BuquicchioDepartment of Pathology, Stanford University, Stanford, CA, USA.
Fangyi WangDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0009-0000-8310-3088
Jackson SouthardBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ren SongAllogene Therapeutics, South San Francisco, CA, USA.
Wenjing LiAllogene Therapeutics, South San Francisco, CA, USA.
Aastha ShresthaAllogene Therapeutics, South San Francisco, CA, USA.
Laxmi ParidaIBM Research, New York, NY, USA.ORCID 0000-0002-7872-5074
Gad GetzHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-0936-0753
Marcela V MausHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-7578-0393
Shuqiang LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9106-6141
Alison MooreAllogene Therapeutics, South San Francisco, CA, USA.
Zachary J RobertsAllogene Therapeutics, South San Francisco, CA, USA.
Leif S LudwigBerlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Aimee C TalleurMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.ORCID 0000-0002-6558-6706
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7955-0256
Houman DehghaniAllogene Therapeutics, South San Francisco, CA, USA.
Thomas PertelAllogene Therapeutics, South San Francisco, CA, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3084-2287
Stephen GottschalkDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-3991-7468
Theodore L RothDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3970-9573
Marie J KerstenDepartment of Hematology, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-8904-3802
Catherine J WuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-3348-5054
Robbie G MajznerParker Institute for Cancer Immunotherapy, San Francisco, CA, USA.ORCID 0000-0001-6969-8011
Ansuman T SatpathyDepartment of Pathology, Stanford University, Stanford, CA, USA. satpathy@stanford.edu.ORCID 0000-0002-5167-537X
Gladstone Institutes · USAllogene Therapeutics (United States) · USBroad Institute · USSt. Jude Children's Research Hospital · USStanford University · USMax Delbrück Center · DEUniversity of Amsterdam · NLIBM (United States) · USParker Institute for Cancer Immunotherapy · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSingle-cell Mapping Center for Human Regulatory Elements and Gene ActivityUM1HG012076 · NHGRI · STANFORD UNIVERSITY · PI Michael Ryan Corces, Ansuman Satpathy · 2021 to 2026
$13.8MSingle cell investigation of co-evolution in cancer cells and host cell immune microenvironmentR50CA251956 · NCI · DANA-FARBER CANCER INST · PI Shuqiang Li · 2020 to 2026
$1.4MCharting somatic evolution via single-cell multiomicsR00HG012579 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI LAREAU, CALEB ANDREW · 2023 to 2025
$747kCharting somatic evolution via single-cell multiomicsK99HG012579 · NHGRI · STANFORD UNIVERSITY · PI LAREAU, CALEB ANDREW · 2022 to 2022
$119kNCI NIH HHS P30 CA008748NCI NIH HHS R50 CA251956NHGRI NIH HHS K99 HG012579NHGRI NIH HHS R00 HG012579NHGRI NIH HHS UM1 HG012076
Abstract
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a comprehensive understanding of the mechanisms of toxicities observed in patients receiving T cell therapies, including recent reports of encephalitis caused by reactivation of human herpesvirus 6 (HHV-6)
Indexed as
CD4-Positive T-LymphocytesHerpesvirus 6, HumanImmunotherapy, AdoptiveReceptors, Chimeric AntigenVirus ActivationVirus LatencyClinical Trials as TopicGene Expression Regulation, ViralGenomicsHumansInfectious EncephalitisRoseolovirus InfectionsSingle-Cell Gene Expression AnalysisViral LoadReceptors, Chimeric Antigen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.