ArticleISME communications2022
Prevalent emergence of reciprocity among cross-feeding bacteria.
Article in ISME communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- Low Levels of Amino Acid Auxotrophy Among Environmental Pseudomonas Isolates.Environmental microbiology · 2026Article
- Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.Applied and environmental microbiology · 2026Article
- Properties and ecological assembly mechanisms of microbial communities across salinity levels in coastal saline-alkaline soils.BMC plant biology · 2026Article
- Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria.Scientific reports · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Colored Plastic Pollution Reshapes Aquatic Microbial Community and Resistance Profile via Divergent Pseudonatural Dissolved Organic Matter.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An experimental outlook on investigating temporal-scale dynamics of microbial communities.ISME communications · 2026Article
- Asymmetric interactions and feast-famine cycles drive chaos in microbial populations.Research square · 2025Article
- Strengthen or Weaken: Evolutionary Directions of Cross-Feeding After Formation.Environmental microbiology reports · 2025Review
- Early-stage reciprocal cooperation between the arbuscular mycorrhizal fungus Rhizophagus irregularis and the phosphate-solubilizing bacterium Rahnella aquatilis is dependent on external phosphorus availability.Communications biology · 2025Article
- Systematic pairwise co-cultures uncover predominant negative interactions among human gut bacteria.Microbiome · 2025Article
- Branched-chain amino acid metabolism supports Roseobacteraceae positive interactions in marine biofilms.Applied and environmental microbiology · 2025Article
- Unveiling the hidden world: How arbuscular mycorrhizal fungi and its regulated core fungi modify the composition and metabolism of soybean rhizosphere microbiome.Environmental microbiome · 2024Article
- Community interactions among microbes give rise to host-microbiome mutualisms in an aquatic plant.mBio · 2024Article
- Interspecies interactions in dairy biofilms drive community structure and response against cleaning and disinfection.Biofilm · 2024Article
- Rhizobacterial syntrophy between a helper and a beneficiary promotes tomato plant health.The ISME journal · 2024Article
- Metabolic exchanges are ubiquitous in natural microbial communities.Nature microbiology · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Explaining the de novo evolution of obligate cooperative cross-feeding interactions among bacteria is a fundamental problem. A critical step during this process is the emergence of reciprocity among two interaction partners, because a mutually beneficial exchange of metabolic byproducts can subsequently favour the evolution of cooperative cross-feeding. However, so far, the propensity with which unidirectional cross-feeding interactions transition into bidirectional interactions remains unknown. To address this issue, we systematically cocultured four amino acid auxotrophic genotypes of two bacterial species with potential amino acid donors belonging to 25 different bacterial species. Surprisingly, the results of this experiment revealed that in around 40% of all cases analysed, both the auxotrophic recipient and the metabolically autonomous donor gained a significant growth advantage in coculture. Subsequent experiments clarified that the auxotrophy-causing mutation did not induce the growth-enhancing effect of recipients, but that it was rather due to a generally high propensity of different species to engage in synergistic metabolic interactions. Together, these findings show that reciprocity commonly emerges spontaneously in unidirectional cross-feeding interactions, thus paving the way for the evolution of even tighter metabolic interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.