ArticleISME communications2022
Phage-encoded ribosomal protein S21 expression is linked to late-stage phage replication.
Article in ISME communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere.bioRxiv : the preprint server for biology · 2026Article
- Linear-time prediction of proteome-scale microbial protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comment on "A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere" by Isaac Meza-Padilla et al.The ISME journal · 2026Article
- A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere.The ISME journal · 2026Article
- Evidence that ribosomal protein bS21 is a component of the OLE ribonucleoprotein complex.RNA biology · 2025Article
- Isolation and characterization of a novel phage belonging to a new genus against Enterococcus faecium.BMC microbiology · 2025Article
- Exploring phage-host interactions inMicrobiology spectrum · 2025Article
- Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells.Nature communications · 2025Article
- COBRA improves the completeness and contiguity of viral genomes assembled from metagenomes.Nature microbiology · 2024Article
- How Dedicated Ribosomes Translate a Leaderless mRNA.Journal of molecular biology · 2024Article
- Exploring the transcriptional landscape of phage-host interactions using novel high-throughput approaches.Current opinion in microbiology · 2024Review
- Exploring virus-host-environment interactions in a chemotrophic-based underground estuary.Environmental microbiome · 2024Article
- Eukaryotic viruses encode the ribosomal protein eL40.Npj viruses · 2024Article
- Structural insight into translation initiation of thebioRxiv : the preprint server for biology · 2023Article
- Ribosome heterogeneity results in leader sequence-mediated regulation of protein synthesis inJournal of bacteriology · 2023Article
- Ribosomes lacking bS21 gain function to regulate protein synthesis in Flavobacterium johnsoniae.Nucleic acids research · 2023Article
- Variable impact of geochemical gradients on the functional potential of bacteria, archaea, and phages from the permanently stratified Lac Pavin.Microbiome · 2023Article
- A Ribosomal Protein Homolog Governs Gene Expression and Virulence in a Bacterial Pathogen.Journal of bacteriology · 2022Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ribosomal protein S21 (bS21) gene has been detected in diverse viruses with a large range of genome sizes, yet its in situ expression and potential significance have not been investigated. Here, we report five closely related clades of bacteriophages (phages) represented by 47 genomes (8 curated to completion and up to 331 kbp in length) that encode a bS21 gene. The bS21 gene is on the reverse strand within a conserved region that encodes the large terminase, major capsid protein, prohead protease, portal vertex proteins, and some hypothetical proteins. Based on CRISPR spacer targeting, the predominance of bacterial taxonomic affiliations of phage genes with those from Bacteroidetes, and the high sequence similarity of the phage bS21 genes and those from Bacteroidetes classes of Flavobacteriia, Cytophagia and Saprospiria, these phages are predicted to infect diverse Bacteroidetes species that inhabit a range of depths in freshwater lakes. Thus, bS21 phages have the potential to impact microbial community composition and carbon turnover in lake ecosystems. The transcriptionally active bS21-encoding phages were likely in the late stage of replication when collected, as core structural genes and bS21 were highly expressed. Thus, our analyses suggest that the phage bS21, which is involved in translation initiation, substitutes into the Bacteroidetes ribosomes and selects preferentially for phage transcripts during the late-stage replication when large-scale phage protein production is required for assembly of phage particles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.