Evidence map›Paper›PMID 37938641›Full record

ArticleISME communications2021

Null-model-based network comparison reveals core associations.

Lisa Röttjers, Doris Vandeputte, Jeroen Raes, Karoline Faust

Abstract read
In one paragraph

Article in ISME communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Geographic variation in the microbiome of Varroa destructor in the neighbouring countries Slovakia and Czechia.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  5. Article
  6. Functional redundancy and niche specialization in honeybee and Varroa microbiomes.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  7. Article
  8. Differential Impact of Simultaneous or Sequential Coinfections WithInternational journal of microbiology · 2025
    Article
  9. Microbial community variations in adultFrontiers in microbiology · 2025
    Article
  10. Differential impact ofHeliyon · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Dynamic nesting ofEcology and evolution · 2024
    Article
  16. Article
  17. Impact ofPathogens (Basel, Switzerland) · 2024
    Article
  18. Exploring the impact ofCurrent research in parasitology & vector-borne diseases · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lisa RöttjersLaboratory of Molecular Bacteriology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-1162-5092
Doris VandeputteLaboratory of Molecular Bacteriology, Rega Institute, KU Leuven, Leuven, Belgium.
Jeroen RaesLaboratory of Molecular Bacteriology, Rega Institute, KU Leuven, Leuven, Belgium.
Karoline FaustLaboratory of Molecular Bacteriology, Rega Institute, KU Leuven, Leuven, Belgium. karoline.faust@kuleuven.be.ORCID http://orcid.org/0000-0001-7129-2803

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 801747Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 30770923KU Leuven (Katholieke Universiteit Leuven) STG/16/006
6 · The paper itself

Abstract

Microbial network construction and analysis is an important tool in microbial ecology. Such networks are often constructed from statistically inferred associations and may not represent ecological interactions. Hence, microbial association networks are error prone and do not necessarily reflect true community structure. We have developed anuran, a toolbox for investigation of noisy networks with null models. Such models allow researchers to generate data under the null hypothesis that all associations are random, supporting identification of nonrandom patterns in groups of association networks. This toolbox compares multiple networks to identify conserved subsets (core association networks, CANs) and other network properties that are shared across all networks. We apply anuran to a time series of fecal samples from 20 women to demonstrate the existence of CANs in a subset of the sampled individuals. Moreover, we use data from the Global Sponge Project to demonstrate that orders of sponges have a larger CAN than expected at random. In conclusion, this toolbox is a resource for investigators wanting to compare microbial networks across conditions, time series, gradients, or hosts.

Identifiers

PMID37938641
PMCPMC9723671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.