ArticleNature communications2023
Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Loss-Engineered Terahertz Pixelated Metasensors for Enhanced Molecular Vibrational Fingerprint Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Raman reporters for SERS/SERRS biosensing and biomedicine: design, applications, and challenges.Mikrochimica acta · 2026Review
- Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.Chemical reviews · 2026Review
- Twist-encoded magnetic plasmon interferometry for label-free, orientation-resolved single-molecule imaging.Science advances · 2026Article
- Rapid on-site SERS detection of difenoconazole and flusilazole in environmental water using an AuNSs/COF-based plate.Mikrochimica acta · 2026Article
- DNA-programmed galvanic Ostwald ripening in nanoparticle assemblies.Nature communications · 2026Article
- AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.Biosensors · 2026Review
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- Electrolyte- and Hydrodynamics-Controlled Potentiostatic Growth of Ag Nanodendrites on Metallic Ti for SERS Detection.ACS omega · 2026Article
- Next-Generation SERS Probes: Engineering Hotspots, Intelligent Molecular Targeting, and AI-Driven Spectral Analysis for Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles.Science advances · 2026Article
- Bioanalysis Using Surface-Enhanced Raman Spectroscopy: From the Perspective of Single Molecules.ACS nano · 2026Review
- Label-Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Self-Assembled Rhodium Nanoantennas for Single-Protein UV SERS.Nanophotonics (Berlin, Germany) · 2026Article
- DNA origami-engineered gold nanoparticle multimers for ultrasensitive, label-free SERS detection of small molecules and biomolecules.RSC advances · 2026Article
- Advances in surface-enhanced Raman scattering applications for precision agriculture: monitoring plant health and crop quality.RSC advances · 2025Review
- DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Dark-Field Scattering Imaging and Spectroscopy.ACS applied materials & interfaces · 2025Review
- Wide-Field Digital Surface-Enhanced Raman Scattering: Quantitative Single-Molecule Detection with High Sensitivity and Throughput.Chemical & biomedical imaging · 2025Article
- Precision-Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart-Warning of Weightlessness Induced Bone Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The label-free identification of individual proteins from liquid samples by surface-enhanced Raman scattering (SERS) spectroscopy is a highly desirable goal in biomedical diagnostics. However, the small Raman scattering cross-section of most (bio-)molecules requires a means to strongly amplify their Raman signal for successful measurement, especially for single molecules. This amplification can be achieved in a plasmonic hotspot that forms between two adjacent gold nanospheres. However, the small (≈1-2 nm) gaps typically required for single-molecule measurements are not accessible for most proteins. A useful strategy would thus involve dimer structures with gaps large enough to accommodate single proteins, whilst providing sufficient field enhancement for single-molecule SERS. Here, we report on using a DNA origami scaffold for tip-to-tip alignment of gold nanorods with an average gap size of 8 nm. The gaps are accessible to streptavidin and thrombin, which are captured at the plasmonic hotspot by specific anchoring sites on the origami template. The field enhancement achieved for the nanorod dimers is sufficient for single-protein SERS spectroscopy with sub-second integration times. This design for SERS probes composed of DNA origami with accessible hotspots promotes future use for single-molecule biodiagnostics in the near-infrared range.
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