Evidence map›Paper›PMID 37938562›Full record

ArticleNature communications2023

Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms.

Louis Tung Faat Lai, Jayashree Balaraman, Fei Zhou, Doreen Matthies

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Nanozyme-Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Structure and function of the human mitochondrial MRS2 channel.Nature structural & molecular biology · 2025
    Article
  14. Article
  15. Article
  16. MRS2 missense variation at Asp216 abrogates inhibitory MgProtein science : a publication of the Protein Society · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Louis Tung Faat LaiUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0003-1413-7035
Jayashree BalaramanUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Fei ZhouUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Doreen MatthiesUnit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. doreen.matthies@nih.gov.ORCID 0000-0001-9221-4484
National Institutes of Health · US

Funding

Towards high-resolution structural biology of membrane protein complexes in their native lipid environmentZIAHD008998 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MATTHIES, DOREEN · 2021 to 2025
$10.7M
Intramural NIH HHS ZIA HD008998
6 · The paper itself

Abstract

Magnesium ions (Mg

Indexed as

AgaricalesMagnesiumCation Transport ProteinsCryoelectron MicroscopyHumansMitochondriaMitochondrial MembranesMitochondrial ProteinsTranslocation, GeneticCation Transport ProteinsMagnesiumMitochondrial ProteinsMRS2 protein, human

Identifiers

PMID37938562
PMCPMC10632456
OpenAlexW4388500134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.